【摘要】 目的 观察xSPECT Quant联合唾液腺显像（SGS）评估分化型甲状腺癌（DTC）甲状腺全切术后¹³¹I治疗前患者腮腺和残留甲状腺功能的价值。方法 前瞻性纳入60例拟接受¹³¹I治疗的甲状腺全切术后DTC患者，于¹³¹I治疗前日行头颈部xSPECT Quant断层融合显像及SGS,计算左、右侧及整体腮腺摄取指数（UI）、最大排泌率（MSR）、最大标准摄取值(SUV_max)、平均标准摄取值(SUV_mean)及残留甲状腺SUV_max、SUV_mean;根据xSPECT Quant断层图像中颈部存在残留甲状腺组织与否将患者分为残留组（n=32）和无残留组（n=28）,依照参数分析法评估腮腺功能结果而分为功能正常组（n=43）和功能受损组（n=17）;观察xSPECT Quant联合SGS评估腮腺和残留甲状腺功能的价值。结果 功能正常组与功能受损组左、右侧腮腺UI及SUV_mean差异均有统计学意义（P均<0.05）,腮腺整体UI与SUV_max,MSR与SUV_max、SUV_mean均呈低度相关（r=0.356、0.327、0.380,P均<0.01）,而UI与SUV_mean呈中度相关（r=0.531,P<0.01）。残留组与无残留组24 h摄碘率差异有统计学意义（P<0.05）,且残留甲状腺SUV_max与24 h摄碘率呈低度相关（r=0.381,P<0.05）。结论 xSPECT Quant联合SGS对评估DTC甲状腺全切术后¹³¹I治疗前患者腮腺和残留甲状腺功能具有一定价值，可初步筛查腮腺功能障碍并评估残留甲状腺的摄碘能力。更多还原

【Abstract】 Objective To observe the value of xSPECT Quant combined with salivary gland scintigraphy（SGS） for evaluating parotid gland function and residual thyroid gland in patients with differentiated thyroid carcinoma（DTC） after total thyroidectomy and before ¹³¹I treatment. Methods Totally 60 DTC patients after total thyroidectomy who would underwent ¹³¹I treatment were prospectively enrolled. Head and neck xSPECT Quant tomographic fusion imaging and SGS were performed the day before ¹³¹I treatment. The uptake index（UI）, maximum excretion rate（MSR）, maximum standard uptake value(SUV_max), mean standard uptake value(SUV_mean) of left, right and whole parotid glands, as well as SUV_max and SUV_mean of the residual thyroid were calculated. The patients were divided into residual group（n=32） and non-residual group（n=28） according to whether with or without residual thyroid tissue on xSPECT Quant tomographic images, also into normal function group（n=43） and impaired function group（n=17） according to results of parametric analysis for parotid gland function. The value of xSPECT Quant combined with SGS for evaluating parotid gland function and residual thyroid gland was evaluated. Results Significant differences of UI and SUV_mean of left and right parotid gland were found between normal function group and impaired function group（all P<0.05）. There were low correlations between UI and SUV_max of whole parotid gland, as well as between MSR and SUV_max, SUV_mean（r=0.356, 0.327, 0.380, all P<0.01）, while UI was moderately correlated with SUV_mean（r=0.531, P<0.01）. Significant difference of 24 h iodine uptake rate was detected between residual group and non-residual group（P<0.05）, while SUV_max of residual thyroid gland was lowly correlated with 24 h iodine uptake rate（r=0.381, P<0.05）. Conclusion xSPECT Quant combined with SGS had certain value for evaluating parotid gland the function and residual thyroid gland in DTC patients after total thyroidectomy before ¹³¹I treatment, which could not only initially screen parotid gland dysfunction, but also evaluate iodine uptake ability of residual thyroid.更多还原