【摘要】 精神分裂症疾病负担沉重，已在全球范围内造成公共卫生影响。其主要治疗方式为药物治疗，然而目前的抗精神病药仍具有一定的局限性。例如对阴性症状、残留阳性症状和认知功能等方面的治疗并不理想，以及药物不良反应和依从性差等问题，均是临床治疗亟需突破的困境。因此，有必要对精神分裂症在国内外的疾病负担、药物治疗现状和困难进行综述，以便帮助临床医师深入理解该病，并为医疗卫生决策者提供参考依据。更多还原

【Abstract】 Schizophrenia is a chronic debilitating mental illness, thus imposing a heavy burden and major public health implications all over the world. Although therapy of schizophrenia mainly relies on medication, the current antipsychotic agents are characterized by some limitations. For example, they ameliorate mainly positive symptoms, while negative and cognitive symptoms remain untreated. Some of these agents involve severe neurological and metabolic side effects and may lead to poor adherence.These problems often leading to treatment dilemmas in clinical practice. Therefore, it is necessary to summarize the disease burden,the current treatment patterns and difficulties of antipsychotic therapy in schizophrenia at home and abroad, so as to help clinicians deeply understand the disease and provide reference to medical and health decision-makers.更多还原