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基于数据挖掘探讨中医药治疗甲状腺癌术后组方用药规律

A discussion on medication rules of TCM prescription on postoperative thyroid cancer based on data mining

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【作者】 李婷; 孙丰雷;

【Author】 LI Ting;

【通讯作者】 孙丰雷;

【机构】 山东中医药大学第一临床医学院; 山东中医药大学附属医院;

【摘要】 目的:使用中医传承辅助平台系统软件V3.0分析中医药治疗甲状腺癌术后用药规律和特点。方法:使用中国知网、万方数据库、维普数据库检索近10年中医药或中西医结合治疗甲状腺癌术后的相关文献,根据排除标准筛选相关文献,筛选完成后建立数据库,运用频数统计、聚类分析等方法统计中药的使用频率、四气五味、归经和药物功效的分布情况,分析药物相互配伍的规律和特点。结果:共筛选出52首符合标准的方剂,共包含143味中药,用药频次≥10次的中药共18味,排名居前3位的中药为夏枯草、黄芪、玄参。中药药性以寒性药最多,中药药味以甘味药最多,苦味药次之。中药归经以肝经、脾经、肺经为主。常用药对共18对,常用3味药配伍共11组,共含有10味中药,出现频次最高的为玄参-地黄、玄参-夏枯草,频次为15次,聚为3组效果最好。结论:中医药治疗甲状腺癌术后常使用具有补气、养阴、健脾化痰、清热解毒等功效的中药,为今后临床治疗用药提供了相对可靠的参考。

【Abstract】 Objective: To analyze the medication rules and characteristics of TCM prescription on postoperative thyroid cancer by TCM Inheritance Support System V3.0. Methods: The literature of treating postoperative thyroid cancer in TCM or the integrative medicine in the past 10 years was retrieved in CNKI, Wanfang Database, and VIP database. The relevant literature was screened according to the exclusion criteria, and a database was established after screening. The frequency statistics, cluster analysis and other methods were used to calculate the applied frequency, medicinal property, medicinal flavors, meridian tropism, and the effect of TCM medicine. The medication compatibility and characteristics were analyzed finally. Results: A total of 52 prescriptions that met the criteria were screened, including 143TCM medicines, with a total of 18 TCM medicines with a frequency of not less than 10 times, and the top 3 TCM medicines were Xiakucao(Prunella Spica), Huangqi(Astragali Radix), and Xuanshen(Scrophulariae Radix). In terms of medicinal properties of TCM medicine,the proportion of medicines with coldness property was the largest. In terms of medicinal flavors, the proportion of sweet medicines was the largest, followed by bitter medicines. The meridian tropism of TCM medicines was mainly liver meridian, spleen meridian, and lung meridian. There were 18 medicine pairs commonly used. There were 11 groups of commonly used medicines composed of 3 kinds of medicinal materials, containing 10 kinds of medicinal materials in total. The combination with the highest frequency was Xuanshen-Dihuang(Radix Rehmanniae), Xuanshen-Xiakucao, the frequency was 15 times, and the effect was best when grouped into 3 groups.Conclusion: TCM medicine is often used to treat postoperative thyroid cancer with the medicines of replenishing Qi( 气), nourishing Yin( 阴), strengthening spleen and removing phlegm, clearing heat and detoxification and so on, providing a relatively reliable reference for future clinical practice.

  • 【文献出处】 中医临床研究 ,Clinical Journal of Chinese Medicine , 编辑部邮箱 ,2022年28期
  • 【分类号】R273
  • 【下载频次】148
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