【摘要】 目的：研究枳实通降颗粒对开腹直肠癌根治性切除术后患者血清炎症因子、炎症指标、D-二聚体及胃肠功能恢复的影响。方法：将60例患者随机分为两组，每组30例，术后均给予常规治疗措施。术后6～12 h开始，治疗组给予枳实通降颗粒口服，而对照组则予同体积安慰剂口服，疗程为4 d。比较两组患者术后胃肠功能恢复情况及术后第1天、第3天、第5天白细胞计数及血清中C-反应蛋白、降钙素原、D-二聚体、白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α水平的变化。结果：治疗组胃肠功能恢复指标均优于对照组（P <0.01）；术后第1天，治疗组白细胞介素-6及肿瘤坏死因子-α水平低于对照组（P <0.05），但其他各项指标的差异无统计学意义（P> 0.05）；术后第3天、第5天，治疗组白细胞计数、C-反应蛋白、降钙素原、D-二聚体、白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α水平均显著低于对照组（P<0.01）；在肺部感染发生率方面，两组的差异无统计学意义（P>0.05）；但在总并发症发生率方面比较，两组的差异有统计学意义（P <0.05）。结论：枳实通降颗粒能显著降低开腹直肠癌术后患者血清中炎症因子、炎症指标及D-二聚体的水平，改善机体血液的高凝状态，有效促进术后患者胃肠功能恢复，防治术后炎性肠梗阻。更多还原

【Abstract】 Objective: To study the effect of the Zhishi Tongjiang granules(枳实通降颗粒) on serum inflammatory factors, inflammatory indexes, D-dimer and gastrointestinal function recovery of postoperative patients with rectal cancer. Methods: A total of 60 cases were randomly divided into two groups, with 30 cases in each group. Routine treatments were given postoperatively in both groups. From 6 to 12 hours after operation, the treatment group was given the Zhishi Tongjiang granules orally, while the control group was given the same volume of placebo orally, and the course of treatment was 4 days. Results: The indexes of gastrointestinal function recovery in the treatment group were better than the control group(P< 0.01). On the first day after operation, the levels of interleukin-6 and tumor necrosis factor-αin the treatment group were lower than those in the control group(P<0.05), but there was no significant difference in other indicators(P>0.05). On the 3 rd and 5th days after operation, the levels of leukocyte, C-reactive protein, procalcitonin, D-dimer, interleukin-6,interleukin-8 and tumor necrosis factor-α in the treatment group were all significantly lower than those in the control group(P<0.01). There was no significant difference in the incidence of pulmonary infection between the two groups(P>0.05). However, there was a statistically significant difference in the incidence of total complications between the two groups(P<0.05). Conclusion: The Zhishi Tongjiang granules can significantly reduce the levels of inflammatory factors, inflammatory indicators and D-dimer in serum of postoperative patients with rectal cancer, relieve the hypercoagulable state of the body, effectively promote the recovery of gastrointestinal function, and prevent postoperative inflammatory ileus.更多还原