【摘要】 目的：观察益气化浊胶囊对高脂饮食大鼠胰岛素抵抗（Insulin Resistance,IR）的预防作用，并初步探讨其可能的作用机制。方法：将SD大鼠随机分为空白对照组、模型对照组、盐酸二甲双胍组(0.2 g·kg^-1·d^-1)和益气化浊胶囊高、中、低剂量组(2 g·kg^-1·d^-1、1 g·kg^-1·d^-1、0.5 g·kg^-1·d^-1)，每组10只。灌胃给药，每日1次，连续8周。给药的同时造模，造模采用高脂饮食喂养诱导IR法。实验期间观察大鼠一般情况，灌胃第8周末，测量体质量、身长，计算Lee’s指数，快速血糖仪测空腹血糖，酶联免疫吸附法检测血清白脂素、胰岛素水平，计算稳态模式评估法胰岛素抵抗指数（Homeostasis Model Assessment of Insulin Resistance Index,HOMA-IR）来评价IR水平。结果：灌胃第8周末时，模型对照组体质量、身长、Lee’s指数、胰岛素水平、HOMA-IR、白脂素水平显著高于空白对照组（P <0.01）；而二甲双胍组、益气化浊胶囊高剂量组体质量、身长显著低于模型对照组（P <0.01或P <0.05），二甲双胍组Lee’s指数显著低于模型对照组（P <0.05），二甲双胍组及益气化浊胶囊高、中剂量组胰岛素水平、HOMA-IR、白脂素水平显著低于模型对照组（P <0.01或P <0.05）。结论：益气化浊胶囊可在一定程度上预防高脂饮食大鼠IR，其作用机制可能与血清白脂素水平的降低有关。更多还原

【Abstract】 Objective: To observe the preventive effect of the Yiqi Huazhuo capsules（ 益气化浊胶囊） on insulin resistance in rats with high-fat diet, and to explore its possible mechanism. Methods: SD rats were randomly divided into the blank control group, the model control group, the metformin hydrochloride group(0.2 g·kg^-1·d^-1) and the high, middle and low dose groups of the Yiqi Huazhuo capsules(2 g·kg^-1·d^-1, 1 g·kg^-1·d^-1, 0.5 g·kg^-1·d^-1), 10 rats in each group. Gavage was given once a day, for 8 consecutive weeks. At the same time of administration, the IR rats models were made by high-fat diet feeding induction method. Results: At the end of the 8th week, the body weight, body length, Lee’s index, insulin level, HOMA-IR and asprosin level in the model control group were significantly higher than those in the blank control group（P<0.01）, while the body weight, and body length in the metformin hydrochloride group and the high dose group of the Yiqi Huazhuo capsules were significantly lower than the model control group（P<0.01 or P<0.05）, the Lee’s index in the metformin hydrochloride group was significantly lower than the model control group（P<0.05）, and the insulin level, HOMA-IR, and asprosin level in the metformin hydrochloride group, the high and middle dose groups of the Yiqi Huazhuo capsules were significantly lower than the model control group（P<0.01 or P<0.05）. Conclusion: The Yiqi Huazhuo capsules can prevent from IR in rats with high-fat diet to some extent, and its mechanism may be related to the decrease of serum asprosin level.更多还原