【摘要】 目的 了解2002—2021年宁波市肝癌死亡趋势，为完善肝癌防控措施提供依据。方法 通过宁波市慢性病监测系统收集2002—2021年宁波市肝癌死亡资料，分析肝癌粗死亡率、标化死亡率（采用2000年全国标准人口构成）和死因链中伴随疾病构成；采用年度变化百分比（APC）和平均年度变化百分比（AAPC）分析肝癌死亡变化趋势。结果 2002—2021年宁波市肝癌粗死亡率和标化死亡率均呈逐年下降趋势，AAPC值分别为-3.47%（95%CI:-4.08%～-2.85%,P<0.001）和-6.56%（95%CI:-7.25%～-5.87%,P<0.001），其中2006—2021年的下降幅度大于2002—2006年；年均粗死亡率为35.39/10万，标化死亡率为20.98/10万。男性肝癌粗死亡率为52.69/10万，女性为18.13/10万；调整年龄后，男性肝癌死亡的危险度是女性的3.03倍（95%CI:2.96～3.09）。随年龄增长，肝癌死亡率呈上升趋势(χ_趋势²=45 684.254,P<0.001)。9 985例肝癌死亡病例死因链中有伴随疾病，占肝癌死亡总数的24.44%，伴随疾病主要为消化系统疾病（多为肝疾病）和传染病寄生虫病（多为病毒性肝炎）。结论 2002—2021年宁波市肝癌死亡率呈下降趋势，男性和中老年人群是肝癌死亡重点关注人群。死因链中伴随疾病以消化系统疾病和传染病寄生虫病为主。更多还原

【Abstract】 Objective To analyze the trend in the mortality of liver cancer in Ningbo City from 2002 to 2021, so as toprovide the evidence for improving the liver cancer control measures.Methods The liver cancer mortality data in Ning-bo City from 2002 to 2021 were collected from Ningbo Municipal Chronic Disease Surveillance System. The crude mor-tality and standardized mortality by the 2 000 national population census data of liver cancer were estimated, and theproportion of concomitant diseases was analyzed among all dead patients with liver cancer. In addition, the trends in liv-er cancer mortality were analyzed with annual percentage change(APC) and average annual percentage change(AAPC).Results Both the crude and standardized mortality of liver cancer appeared a tendency towards a decline year by yearin Ningbo City from 2002 to 2021, with AAPC of-3.47%(95%CI:-4.08% to-2.85%, P<0.001) and-6.56%(95%CI:-7.25% to-5.87%, P<0.001), and a the decline in liver cancer mortality was larger during the period between 2006and 2021 than during the period between 2002 and 2006. The annual mean crude and standardized mortality of livercancer was 35.39/105 and 20.98/105, and the crude mortality of liver cancer was 52.69/105in men and 18.13/105inwomen, respectively. After adjustment for age, the risk of liver cancer mortality was 3.03(95%CI: 2.96-3.09) timesgreater among men than among women, and the mortality of liver cancer appeared a tendency towards a rise with age(χ~2trend=45 684.254, P<0.001). Concomitant diseases were found among 9 985 dead cases with liver cancer(24.44%),and the concomitant diseases mainly included digestive system diseases(predominantly liver diseases) and infectious andparasitic diseases(predominantly virus hepatitis).Conclusions The mortality of liver cancer appeared a tendency to-wards a decline in Ningbo City from 2002 to 2021, and men and middle-aged and elderly residents were at high riskof liver cancer mortality. Digestive system diseases and infectious and parasitic diseases were predominant concomitantdiseases among dead patients with liver cancer.更多还原