【摘要】 目的 探究学龄前肥胖儿童体内激素和维生素D水平与肥胖的关系。方法 选择2020年1月至2021年10月符合肥胖诊断标准的128例学龄前儿童作为研究对象，根据血清维生素D水平分为维生素D适宜组(n=42),维生素D不足组(n=53),维生素D缺乏组(n=33)。比较3组儿童糖脂代谢水平以及维生素D、促性腺激素、3,5,3′-三碘甲腺原氨酸(T3)、甲状腺素(T4)、甲状旁腺激素水平，并通过Person法分析维生素D水平与糖脂代谢和激素水平的相关性。结果 维生素D缺乏组儿童空腹葡萄糖水平(FBG)、血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平以及血清T3、T4、甲状旁腺激素水平低于适宜组和不足组，甘油三酯(TG)、促性腺激素和低密度脂蛋白胆固醇(LDL-C)水平则高于适宜组和不足组，差异有统计学意义(P<0.05)。缺乏组和不足组的维生素D水平与儿童糖脂代谢指标和T3、T4、甲状旁腺激素水平均存在相关性(P<0.05),维生素D适宜组则与儿童糖脂代谢指标之间无显著相关性(P>0.05)。结论 缺乏和不足儿童的维生素D水平与糖脂代谢和激素水平存在相关性。更多还原

【Abstract】 Objective To explore the relationship between the levels of hormones and vitamin D and obesity in obese preschool children.Methods A total of 128 preschoolers who met the diagnostic criteria for obesity were selected as research subjects. According to the serum vitamin D level, they were divided into appropriate vitamin D group(n=42), insufficient vitamin D group(n=53) and deficient vitamin D group(n=33). The glucolipid metabolism level, vitamin D,Gn, T3, T4 and parathyroid hormone levels of the three groups were compared and analyzed, and the correlation between vitamin D level and the levels of glucolipid metabolism and various hormones levels was analyzed by Person method.Results The levels of FBG, TC, HDL-C, Gn, T3, T4 and parathyroid hormone in vitamin D deficiency group were lower than those in appropriate group and insufficiency group, while the levels of TG and LDL-C were higher(P<0.05). There was a significant correlation between the vitamin D level of deficiency group and insufficiency group and the glucolipid metabolism indexes of children and the levels of T3, T4 and parathyroid hormone(P<0.05), but there was no significant correlation with glucolipid metabolism indexes of children in the appropriate vitamin D group(P>0.05).Conclusion Vitamin D levels in deficiency and insufficiency groups of children are correlated with glucolipid metabolism and hormone levels.更多还原