【摘要】 目的：比较两种不同胸腔镜术对老年Ⅰ、Ⅱ期非小细胞肺癌（NSCLC）患者炎症反应、生活质量的影响。方法：将九江市第一人民医院2021年1月30日-2022年1月30日接收50例老年Ⅰ、Ⅱ期NSCLC患者按照随机分组法分为研究组（n=25，单孔胸腔镜术治疗）、对照组（n=25，单操作孔胸腔镜术治疗），对比两者的临床指标、炎症因子[高敏C反应蛋白（hs-CRP）、白细胞介素（IL-6）、前列腺素E₂（PGE₂）]水平、生活质量及并发症。结果：两组手术时间、淋巴结清扫数目比较，差异均无统计学意义（P>0.05）；研究组住院时间短于对照组（P<0.05），术中出血量少于对照组（P<0.05）；研究组术后7 d的IL-6、PGE₂、hs-CRP水平均低于对照组（P<0.05）；研究组术后3个月生活质量8个维度评分均显著高于本组治疗前，且研究组均高于对照组（P<0.05）；研究组的并发症发生率为8.00%，低于对照组的32.00%（P<0.05）。结论：较单操作孔胸腔镜术，单孔胸腔镜术治疗老年Ⅰ、Ⅱ期NSCLC，可缩短患者的住院时间，减少术中出血量，提高患者的生活质量，术后炎症反应更低，并发症更少，安全性更高，值得推广应用。更多还原

【Abstract】 Objective:To compare the effects of two different thoracoscopy on inflammatory response and quality of life in elderly patients with stageⅠ,Ⅱnon-small cell lung cancer （NSCLC）.Method:From January30,2021 to January 30,2022,50 elderly patients with stageⅠ,ⅡNSCLC in Jiujiang NO.1 People’s Hospital were divided into the study group （n=25,treated by single-port thoracoscopy） and the control group （n=25,treated by single-operating port thoracoscopic surgery） according to randomization method.The clinical indicators and inflammatory factor[high-sensitivity C reactive protein （hs-CRP）,interleukin （IL-6）,prostaglandin E₂ （PGE₂）]levels,quality of life and complications in two groups were compared.Result:There were no significant differences in the operation time and the number of lymph node dissection between the two groups （P>0.05）.The length of hospital stay in the study group was shorter than that in the control group （P<0.05）,and the intraoperative blood loss was less than that in the control group （P<0.05）.Seven days after operation,the levels of IL-6,PGE₂ and hs-CRP in the study group were lower than those in the control group （P<0.05）.The scores of 8 dimensions of quality of life in the study group 3 months after operation were significantly higher than those before treatment,and those in the study group were higher than those in the control group （P<0.05）.The incidence of complications in the study group was8.00%,which was lower than 32.00%in the control group （P<0.05）.Conclusion:Compared with single-operating port thoracoscopic surgery,single-port thoracoscopic surgery in the treatment of elderly patients with stageⅠ,ⅡNSCLC can shorten the hospitalization time,reduce the amount of intraoperative blood loss,improve the quality of life of patients.The postoperative inflammatory response is lower,the complications are less,the safety is higher,and it is worthy of popularization and application.更多还原