【摘要】 目的：探讨罗哌卡因复合小剂量右美托咪定用于剖宫产术蛛网膜下腔阻滞中的效果。方法：选取2021年1-12月于赣州市妇幼保健院收治的行剖宫产术的60例患者作为研究对象，采用随机数字表法将其分为对照组和观察组，每组30例。两组均采用蛛网膜下腔麻醉，对照组蛛网膜下腔注射罗哌卡因，观察组蛛网膜下腔注射罗哌卡因复合小剂量右美托咪定。比较两组患者麻醉前（T₀）、注药后5 min（T₁）、注药后10 min（T₂）、注药后15 min（T₃）、术毕即刻（T₄）的心率（HR）、平均动脉压（MAP）、血氧饱和度（SpO₂）及感觉阻滞时间（起效时间、持续时间、峰值时间）、运动阻滞时间（起效时间、持续时间）、不良反应情况。结果：观察组T₁、T₂、T₃的HR、MAP均低于对照组，差异均有统计学意义（P<0.05）；两组T₀、T₄的HR、MAP及各时刻SpO₂比较，差异均无统计学意义（P>0.05）；两组T₁、T₂、T₃的HR均高于T₀，两组T₁、T₂、T₃、T₄的MAP均高于T₀，差异均有统计学意义（P<0.05）。观察组感觉阻滞起效时间、感觉阻滞峰值时间、运动阻滞起效时间均早于对照组，观察组感觉阻滞持续时间、运动阻滞持续时间均长于对照组，观察组不良反应总发生率低于对照组，差异均有统计学意义（P<0.05）。结论：罗哌卡因复合小剂量右美托咪定在剖宫产术蛛网膜下腔麻醉中效果理想，具有起效快、麻醉效果确切、不良反应发生风险低的优势，且对患者心率、平均动脉压影响较小，临床应用价值高。更多还原

【Abstract】 Objective:To explore the effect of Ropivacaine combined with low-dose Dexmedetomidine in subarachnoid block of cesarean section.Method:From January to December 2021,60 patients who underwent cesarean section in Ganzhou Maternal and Child Health Hospital were selected as the research objects,and they were divided into the observation group （n=30） and the control group （n=30） by random number table method.Subarachnoid anesthesia was used in two groups.The control group received subarachnoid injection of Ropivacaine,and the observation group received subarachnoid injection of Ropivacaine combined with low-dose Dexmedetomidine.The heart rate （HR） and mean arterial pressure （MAP）,blood oxygen saturation （SpO₂） before anesthesia （T₀）,5 min after drug injection （T₁）,10 min after drug injection （T₂）,15 min after drug injection （T₃）,and immediately after surgery （T₄） and sensory block time （onset time,duration time,peak time）,motor block time （onset time,duration time）,total incidence of adverse reactions were compared between the two groups of patients.Result:The HR and MAP of T₁,T₂ and T₃ in the observation group were lower than those in the control group,the differences were statistically significant （P<0.05）.There were no significant differences in HR,MAP of T₀ and T₄ and SpO₂ at each time between the two groups （P>0.05）.HR of T₁,T₂ and T₃ were higher than that of T₀,and MAP of T₁,T₂,T₃ and T₄ were higher than that of T₀ in the two groups,the differences were statistically significant （P<0.05）.The onset time of sensory block,peak time of sensory block and onset time of motor block in the observation group were earlier than those in the control group,the duration of sensory block and motor block in the observation group were longer than those in the control group,and the total incidence of adverse reactions in the observation group was lower than that in the control group,the differences were all statistically significant （P<0.05）.Conclusion:Ropivacaine combined with low-dose Dexmedetomidine has an ideal effect in subarachnoid anesthesia for cesarean section,with the advantages of fast onset,accurate anesthesia effect,and low risk of adverse reactions.It has little influence on HR and mean arterial pressure and has high clinical application value.更多还原