【摘要】 多囊卵巢综合征(PCOS)是育龄妇女最常见的内分泌失调之一，会导致严重影响女性身心健康的各种并发症，如不孕、子宫内膜病变、心血管疾病、代谢紊乱及心理问题等。近些年，维生素D缺乏普遍出现在PCOS女性中，说明维生素D可能与PCOS疾病的进展与转归息息相关。由于维生素D是通过维生素D受体(VDR)来调控基因转录的，所以维生素D对PCOS的影响可能与VDR基因多态性有关。本文从维生素D与PCOS的两个主要表征胰岛素抵抗(IR)、高雄激素血症(HA)及VDR与PCOS的关系进行综述。更多还原

【Abstract】 Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in the fertile women,which can lead to various complications that seriously affect women’s physical and mental health,such as infertility,endometrial lesions,cardiovascular diseases,metabolic disorders and psychological problems.In recent years,vitamin D deficiency has generally occurred in PCOS women,indicating that vitamin D may be closely related to the progression and prognosis of PCOS.Since vitamin D regulates gene transcription through vitamin D receptor (VDR),the effect of vitamin D on PCOS may be related to the polymorphism of VDR gene.This paper reviewed the relationship between vitamin D and PCOS,including insulin resistance (IR) and hyperandrogenism (HA),and how VDR affects PCOS.更多还原