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基于数据挖掘分析邵冬珊主任治疗慢性乙型肝炎用药规律

Analysis of drug use of Shao Dongshan in the treatment of chronic hepatitis B based on data mining

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【作者】 柯靖雯; 邵冬珊; 肖明中; 惠晨阳; 贠凡; 袁漫曦;

【Author】 KE Jing-wen;SHAO Dong-shan;XIAO Ming-zhong;Hubei University of Traditional Chinese Medicine;

【通讯作者】 邵冬珊;

【机构】 湖北中医药大学第一临床学院; 湖北省中医院肝病科; 湖北中医药大学附属医院; 湖北省中医药研究院; 湖北省中医院感染性疾病科;

【摘要】 目的:运用数据挖掘技术分析邵冬珊主任治疗慢性乙型病毒性肝炎的用药规律。方法:收集邵冬珊治疗慢性乙型肝炎门诊处方数据,运用Microsoft Excel、SPSS Modeler 18.0及Cytoscape 3.9.1软件,统计处方中的药物使用频次、性味归经及药物之间的关联规则,提取核心药对,分析用药规律。结果:筛选出处方共679张,涉及中药204味,高频用药包含甘草、丹参、败酱草、白术等;药性主要为温性;药味主要为甘味、苦味;归经主要为肝经。关联规则分析显示,枸杞子、半夏-黄芩等为治疗慢性乙型肝炎核心药对。结论:邵冬珊在治疗慢性乙型肝炎方面以扶正气、和枢机、解郁结为主,并根据患者不同证候随证加减。

【Abstract】 Objective:To analyze the medication rule of Shao Dongshan in the treatment of chronic hepatitis B by using data mining technology.Methods:The prescription data of Shao Dongshan in the treatment of chronic hepatitis B were collected, and the frequency of drug use, the menstruation of nature, and taste and the association rules between drugs were calculated by using Microsoft Excel, SPSS Modeler 18.0 and Cytoscape 3.9.1 software. Results:A total of 679 prescriptions of Shao Dongshan in the treatment of chronic hepatitis B was selected, involving 204 traditional Chinese medicines, including licorice, Salvia miltiorrhiza, Patrinia asiatica, Atractylodes macrocephala, etc., which were mainly warm, sweet and bitter, and the meridians were mainly liver meridians. Association rule analysis shows that Chinese wolfberry and Pinellia ternata-Scutellaria baicalensis are the core drugs for the treatment of chronic hepatitis B. Conclusion:Shao Dongshan mainly relieves vital qi, harmonizes cardinal and relieves depression in the treatment of chronic hepatitis B, and adds or decreases with syndrome according to different syndromes of patients.

【基金】 国家中医药管理局慢性肝病肝肾论治项目(No.Z155080000004)
  • 【文献出处】 中西医结合肝病杂志 ,Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases , 编辑部邮箱 ,2022年11期
  • 【分类号】R259;R249
  • 【下载频次】102
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