【摘要】 目的 探讨北京昌平地区孕妇HBV血清标志物与HBV-DNA载量之间的关系，为监控孕期乙肝病毒感染和预防HBV母婴传播提供参考。方法 以2017～2021在北京积水潭医院建档孕妇为研究对象，检测HBV血清标志物五项和HBV-DNA载量，并对结果进行统计分析。结果 15 691例孕妇中HBsAg阳性率为2.09%,5年间HBsAg阳性率逐年降低（P<0.05）,HBsAg阳性率随年龄组别升高而增加（P<0.05）。328例HBsAg阳性孕妇HBV标志物（HBVM）模式有7种，其中模式Ⅰ（HBsAg~+、HBeAg~+、HBcAb~+，大三阳）和Ⅱ（HBsAg~+、HBeAb~+、HBcAb~+，小三阳）共有300例，占7种组合模式的91.46%。328例HBsAg阳性孕妇中，87例HBV-DNA>500copies/ml，其中模式Ⅰ、Ⅱ共79例；7种HBVM模式中HBeAg阳性的孕妇HBV-DNA阳性率（72.97%）高于HBeAg阴性孕妇（20.27%）(P<0.01);HBeAg~+组患者的平均病毒载量高于HBeAg-组（P<0.01）。结论 HBVM与HBV-DNA阳性率及高病毒载量密切相关，产前筛查对孕产妇及新生儿的乙肝预防及干预具有重要意义；孕妇HBVM检测结果中HBsAg~+HBeAg~+者HBV-DNA载量较高，是防控母婴垂直传播的重点。更多还原

【Abstract】 Objective This study showed the relationship between the patterns of HBV markers(HBVM)in serum of the pregnant women and the viral load(VL)of HBV-DNA in Changping,Beijing,which would provide a reference for preventing mother-to-child transmission of HBV during pregnancy.Methods Five serum markers of HBV and the HBV-DNA load in pregnant women of Beijing Ji Shuitan Hospital from 2017to 2021were detected,and the results were statistically analyzed.Results In 15 691pregnant women,the positive rate of HBsAg that was 2.09%,and decreased by years from 2017to 2021,but increased significantly with age(P<0.05).Among the 328HBsAg~+pregnant women,there were 7patterns of HBV markers(HBVM)combination,of which 300cases(91.46%)were Pattern Ⅰ（HbsAg~+HbeAg~+HbcAb~+）andⅡ（HbsAg~+HbeAb~+HbcAb~+）.There were 87cases of HBV-DNA>500copies/ml in the HBsAg~+pregnant women,and 79of the 87patients were PatternⅠandⅡ．The positive rate in HBV-DNA was72.97%in the HBeAg~+pregnant women and was higher than that in the HBeAg-patients(20.27%)(P<0.01).Moreover,the viral load of HBV in HBeAg~+patients was significantly higher than in the HBeAg patients(P<0.01).Conclusion The patterns of HBVM are closely related to the positive rate of HBV-DNA and high VL in serum of patients.Perinatal screening in HBVMs is of great significance for the infection of HBV from the pregnant women to their babies.The HBsAg~+HBeAg~+pregnant women are the focus of the mother-to-child infection blocking in HBV because of their high VL.更多还原