【摘要】 目的 探讨体检人群甲胎蛋白（AFP）升高与血脂六项的关系。方法 选取2020年4月至2021年8月3 283例健康体检者作为研究对象，采集基线资料、总胆固醇（Total cholesterol,TC）、甘油三酯（Triglyceride,TG）、高度脂蛋白（High lipoprotein,HDL）、低密度脂蛋白（Low density lipoprotein,LDL）、载脂蛋白A(Apolipoprotein A,APOA)和载脂蛋白B(Apolipoprotein B,APOB)共计6项血脂指标以及甲胎蛋白（AFP）。依据AFP不同浓度进行分组，比较组间血脂六项水平差异，同时分析AFP水平与血脂六项的相关性；应用Logistic回归分析筛选出影响AFP升高的危险因素；同时比较AFP在血脂异常组和正常组间的水平差异。结果 TC、TG、LDL和APOB 4项血脂指标随着AFP浓度的增加出现了异常率和异常水平的明显上升，差异均具有统计学意义（P<0.05）;Spearman相关性分析显示，AFP与TC、TG、HDL、LDL、APOA、APOB均呈正相关（r=0.120、0.090、0.040、0.097、0.067、0.120,P<0.05）；经二元Logistic回归分析显示，TC是AFP升高的独立危险因素（β=0.223,P<0.05）；血脂异常组相对于血脂正常组AFP水平升高，组间差异具有统计学意义（P<0.05）。结论 健康体检者中AFP升高与TC、TG、LDH和APOB有明显正相关，其中TC是AFP升高的独立危险因素。更多还原

【Abstract】 Objective To explore the relationship between the increase of alpha-fetoprotein(AFP)and six items of serum lipids in physical examination population.Methods 3 283healthy subjects were selected from April 2020to August 2021.The baseline data,alpha-fetoprotein(AFP),and six serum lipid indexes of total cholesterol(TC),triglyceride(TG),high lipoprotein(HDL),low density lipoprotein(LDL),apolipoprotein A(APOA)and apolipoprotein B(APOB)were collected.The patients were divided into groups according to different concentrations of AFP,the differences of levels of six items of serum lipids among groups were compared,and the correlation between the levels of AFP and six items of serum lipids was analyzed.Logistic regression analysis was used to screen out risk factors for the increase of AFP.At the same time,the differences of AFP levels between dyslipidemia group and normal group were compared.Results The abnormal rate and abnormal level of TC,TG,LDL and APOB increased significantly with the increase of AFP concentration,and the spearman correlation analysis showed that AFP was positively correlated with TC,TG,HDL,LDL,APOA and APOB(r=0.120,0.090,0.040,0.097,0.067,0.120,P<0.05).Binary logistic regression analysis showed that TC was an independent risk factor for the increase of AFP(β=0.223,P<0.05),and the level of AFP in dyslipidemia group was significantly higher than that in normal serum lipid group(P<0.05).Conclusion The increase of AFP in healthy subjects is positively correlated with TC,TG,LDH and APOB,and TC is an independent risk factor for the increase of AFP.The continuous increase of AFP levels accompanied by dyslipidemia may help the diagnosis and treatment of fatty liver disease.更多还原