Hog cholera is an economically important disease of swine caused by hog cholera virus (or named classical swine fever virus). This paper stated fully advances of HCV structural protein C、E 0、E 1、E 2 and their applications in prevention and treatment to hog cholera. It was pointed out that there was a great advantage of recombinant vaccine comprising E 0 and E 2 genes to exclude hog cholera .