【摘要】 目的 观察温经通络方熏洗对阿帕替尼手足综合征(HFS)的疗效及安全性。方法 61例接受单药阿帕替尼治疗后出现HFS的患者,采用随机数字表法分为对照组(30例)及试验组(31例)。两组均采用常规干预方法 ,试验组在此基础上接受温经通络方熏洗手足。对比两组患者临床疗效、疼痛程度、不良反应发生情况及治疗前后中医证候积分、卡氏(KPS)评分。结果 试验组患者治疗总有效率为87.10%,高于对照组的40.00%,差异具有统计学意义(P<0.05)。治疗后,两组患者中医证候积分均较本组治疗前降低,且试验组患者中医证候积分(3.67±1.56)分低于对照组的(8.76±2.95)分,差异均有统计学意义(P<0.05)。治疗后,试验组患者KPS评分高于本组治疗前,且试验组患者高于对照组,差异均有统计学意义(P<0.05)。试验组患者疼痛程度低于对照组,差异具有统计学意义(P<0.05)。治疗过程中,两组患者均未发生较为严重的不良反应。结论 阿帕替尼HFS患者采用温经通络方熏洗手足,不仅能够提高患者的临床疗效,还可改善患者症状及生活质量,减轻疼痛,安全性高,值得临床推广应用。更多还原

【Abstract】 Objective To observe the efficacy and safety of fumigation and washing of Wenjing Tongluo recipe on apatinib-induced hand-foot syndrome(HFS). Methods A total of 61 patients with HFS after receiving single-agent apatinib were divided into control group(30 cases) and experimental group(31 cases) according to random numerical table. Both groups were treated with conventional intervention methods, and the experimental group received fumigation and washing of Wenjing Tongluo recipe on this basis. The clinical efficacy, degree of pain, occurrence of adverse reactions, traditional Chinese medicine syndrome scores and Karnofsky performance scale(KPS) score before and after treatment were compared between the two groups. Results The total effective rate in the experimental group was 87.10%, which was higher than 40.00% in the control group, and the difference was statistically significant(P<0.05). After treatment, the traditional Chinese medicine syndrome scores of the two groups were lower than those of this group before treatment, and the traditional Chinese medicine syndrome score(3.67±1.56) points of the experimental group was lower than(8.76±2.95) points of the control group. All the differences were statistically significant(P<0.05). After treatment, the KPS score in the experimental group was higher than that before treatment in this group and that in the control group, and the differences were statistically significant(P<0.05). The pain degree in the experimental group was lower than that in the control group, and the difference was statistically significant(P<0.05). During the treatment, no serious adverse reactions occurred in the two groups. Conclusion The fumigation and washing of Wenjing Tongluo recipe for the prevention and treatment of apatinib-induced HFS patients can not only improve the clinical efficacy, but also improve the symptoms and quality of life of patients, relieve the pain of patients. It has high safety, and is worthy of clinical promotion and application.更多还原