【摘要】 近年来，许多研究表明，激活cGAS-STING-IRF3信号通路可以在体内外产生较强的抗肿瘤作用。利用STING激动剂可以激活cGAS-STING-IRF3信号通路，诱导产生Ⅰ型干扰素，Ⅰ型干扰素可以促进树突状细胞活化，进而激活CD8~+T细胞发挥抗肿瘤作用。活化STING通路，可以调节肿瘤微环境中的各种免疫细胞，并且药物递送系统可以显著提升STING激动剂的抗肿瘤效果。此外，微生物以及机体自身的DNA损伤参与调节cGAS-STING信号通路影响肿瘤免疫的效果。本文将对cGAS-STING通路在肿瘤微环境中的作用进行综述。更多还原

【Abstract】 Recent research has shown that cGAS-STING-IRF3 signaling pathway can be activated to produce potent anti-tumor effect both in vitro and in vivo.The cGAS-STING-IRF3 signaling pathway can be activated by STING agonists,which results in the production of type I interferon.This type of interferon can increase the activation of dendritic cells,and in turn,stimulate CD8~+T lymphocytes to have anti-tumor effect.By turning on the STING pathway,different immune cells in the tumor microenvironment may be affected,and the drug delivery system can significantly boost the anti-tumor effect of STING agonists.Additionally,cGAS-STING pathway is modulated by microorganisms and DNA damage in order to modify anti-tumor immunotherapy.This paper discussed the role of cGAS-STING pathway in the tumor microenvironment.更多还原