【摘要】 目的：观察炔雌醇环丙孕酮联合雷洛昔芬治疗多囊卵巢综合征（PCOS）合并不孕症患者的效果。方法：选取2020年2月至2021年1月该院收治的76例PCOS合并不孕症患者进行前瞻性研究，按照随机数字表法分为研究组与对照组各38例。对照组给予雷洛昔芬治疗，研究组在对照组基础上联合炔雌醇环丙孕酮片治疗，比较两组自然妊娠率、排卵率、正常月经周期率、性激素指标[睾酮（T）、黄体生成素（LH）、促卵泡激素（FSH）]水平、卵巢体积和不良反应发生率。结果：随访6个月，研究组自然妊娠率为50.00%，明显高于对照组的26.32%，差异有统计学意义（P<0.05）；随访6个月，研究组排卵率为84.21%，明显高于对照组的52.63%，差异有统计学意义（P<0.05）；随访6个月，研究组正常月经周期率为92.11%，明显高于对照组的73.68%，差异有统计学意义（P<0.05）；治疗后，两组T、LH、FSH水平和卵巢体积均低于治疗前，研究组低于对照组，差异有统计学意义（P<0.05）；两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：炔雌醇环丙孕酮联合雷洛昔芬治疗PCOS合并不孕症患者可提高其自然妊娠率、排卵率、正常月经周期率，降低其卵巢体积和性激素水平，效果优于单纯雷洛昔芬治疗。更多还原

【Abstract】 Objective: To observe the effect of Ethinylestradiol cyproterone combined with Raloxifene in treatment of patients with polycystic ovary syndrome(PCOS) complicated with infertility. Methods: A prospective study was conducted on 76 patients with PCOS complicated with infertility admitted to this hospital from February 2020 to January 2021. They were divided into study group and control group according to the random number table method, 38 cases in each. The control group was treated with Raloxifene, while the study group was treated with Ethinylestradiol cyproterone tablets on the basis of that of the control group. The spontaneous pregnancy rate, the ovulation rate, the normal menstrual cycle rate, the sex hormone index levels [testosterone(T), luteinizing hormone(LH), follicle stimulating hormone(FSH)], the ovarian volume, and the incidence of adverse reactions were compared between the two groups. Results: After 6 months of follow-up, the spontaneous pregnancy rate of the study group was 50.00%, which was significantly higher than 26.32% of the control group, and the difference was statistically significant(P<0.05).After 6 months of follow-up, the ovulation rate of the study group was 84.21%, which was significantly higher than 52.63% of the control group, and the difference was statistically significant(P<0.05). After 6 months of follow-up, the normal menstrual cycle rate of the study group was 92.11%, which was significantly higher than 73.68% of the control group, and the difference was statistically significant(P<0.05). After the treatment, the levels of T, LH, FSH and ovarian volume in the two groups were lower than those before the treatment, those in the study group were lower than those in the control group, and the differences were statistically significant(P<0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: Ethinylestradiol cyproterone combined with Raloxifene in the treatment of the PCOS patients complicated with infertility can improve the spontaneous pregnancy rate, the ovulation rate, the normal menstrual cycle rate, and reduce the ovarian volume and the sex hormone levels. Moreover, it is superior to single Raloxifene treatment.更多还原