【摘要】 目的：观察苦碟子注射液联合西药治疗急性脑梗死（ACI）患者的效果。方法：选取2018年6月至2020年6月该院收治的82例ACI患者的临床资料进行回顾性研究，按照治疗方法不同分为观察组与对照组各41例。对照组给予常规西药治疗，观察组在对照组基础上给予苦碟子注射液治疗，比较两组疗效、治疗前后美国国立卫生研究院卒中量表（NIHSS）评分、炎性因子[可溶性CD40配体（sCD40L）、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]水平，以及不良反应发生率。结果：观察组治疗总有效率为90.24%(37/41)，高于对照组的68.29%(28/41)，差异有统计学意义（P<0.05）；治疗后，两组NIHSS评分及sCD40L、IL-6和TNF-α水平均低于治疗前，且观察组低于对照组，差异有统计学意义（P<0.05）；治疗期间，两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：在常规西药治疗基础上采用苦碟子注射液治疗ACI患者可提高治疗总有效率，降低NIHSS评分和炎性因子水平，效果优于单纯常规西药治疗。更多还原

【Abstract】 Objective: To observe effects of Kudiezi injection combined with western medicine on patients with acute cerebral infarction(ACI). Methods: The clinical data of 82 ACI patients admitted to this hospital from June 2018 to June 2020 were selected for the retrospective study,and they were divided into observation group and control group according to the different treatment methods, 41 cases in each. The control group was given conventional western medicine treatment, while the observation group was given Kudiezi injection on the basis of that of the control group. The efficacy, the national institutes of health stroke scale(NIHSS) score, the inflammatory factor levels [soluble CD40 ligand(sCD40L), interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)] before and after treatment, and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of the observation group was 90.24%(37/41), which was higher than 68.29%(28/41) of the control group, and the difference was statistically significant(P<0.05). After the treatment, the NIHSS scores and the levels of sCD40L, IL-6 and TNF-α in the two groups were lower than those before the treatment, those of the observation group were lower than those of the control group, and the differences were statistically significant(P<0.05). During the treatment, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions:On the basis of the conventional western medicine treatment, Kudiezi injection in the treatment of the ACI patients can improve the total effective rate of treatment, and reduce the NIHSS score and the levels of inflammatory factors. Moreover, it is superior to single conventional western medicine treatment.更多还原