【摘要】 通过烯烃和硝基芳烃之间的还原偶联合成芳香胺非常具有吸引力。然而，这一方法仍然存在多种挑战。本文报道了一种条件温和的镍催化烯烃与硝基芳烃的还原氢胺化反应。该反应表现出原位选择性，并且能够制备多种含有伯烷基和仲烷基的芳香胺。反应能够耐受多种官能团，为类药胺类化合物的合成提供了有效途径。更多还原

【Abstract】 Aromatic amine synthesis via reductive coupling between alkenes and nitroarenes is attractive; however, it remains underdeveloped. Herein, we report a nickel-catalyzed alkene hydroamination with nitroarenes under mild reductive conditions. This reaction exhibited an ipso-selectivity and enabled repaid preparation of aromatic amines with primary and secondary alkyl groups. Many functional groups were well tolerated, providing an efficient approach for drug-like arylamine synthesis.更多还原