【摘要】 目的 探讨先天性卵圆孔未闭（PFO）相关缺血性卒中患者血清生化和全血细胞特征。方法 入选2020年1月至2021年6月于南昌大学第二附属医院诊断为先天性PFO致缺血性卒中并行介入封堵术的患者91例（PFO组）；匹配同样数目其他病因（非PFO）导致的缺血性卒中患者作为对照组。分析比较两组患者在人口学资料、脑血管传统危险因素、血清生化、全血细胞计数等方面的差异。结果 PFO组患者较对照组平均年龄更小[（55.22±15.18）岁比（64.74±12.14）岁，P<0.001]，且高血压病比例更低（27.47%比69.23%,P<0.001）。PFO组总胆固醇水平低于对照组[（4.15±0.96）mmol/L比（4.52±1.32）mmol/L,P=0.033]，而嗜酸性粒细胞在白细胞计数中占比高于对照组[（2.26±1.76）%比（1.53±1.13）%,P=0.001]。采用受试者工作特征曲线分析嗜酸性粒细胞占比对PFO相关缺血性卒中的诊断效能，结果显示曲线下面积为0.621，最佳临界值为1.42%，诊断敏感度为65.90%，特异度为56.00%。结论 先天性PFO相关缺血性卒中患者临床资料、血清生化及全血细胞计数检测均有其特征性，可为临床尽早识别、辅助缺血性卒中的病因诊断提供参考。更多还原

【Abstract】 Objective To investigate the biochemical parameters and blood count features of ischemic stroke associated with Patent foramen ovale (PFO).Methods A retrospective cohort of 91 consecutive ischemic stroke with PFO patients underwent interventional occlusion in our hospital between January 2020 and June 2021 was recruited.Simultaneously,the same amount of patients diagnosed of stroke of non-PFO reasons were matched as the control.Clinical characteristics,biochemical parameters and complete blood count in two groups were compared.Results Compared to the control group,patients with PFO were younger[(55.22±15.18) years vs.(64.74±12.14)years,P<0.001],lower rate of hypertensive risk factors(27.47%vs.69.23%,P<0.001),with lower cholesterol level[(4.15±0.96)mmol/L vs.(4.52±1.32)mmol/L,P=0.033],with higher eosinophils/white blood cell ratio[(2.26±1.76)%vs.(1.53±1.13)%,P=0.001].The area under the operative receiver curve was 0.621,with the best diagnostic cut-off of 1.42%,sensitivity of 65.90%and specificity of 56.00%.Conclusions Clinical characteristics,biochemical parameters and complete blood count differed in ischemic stroke with PFO,which could provide a reference for early clinical identification and etiological diagnosis of ischemic stroke.更多还原