【摘要】 蛋白质S-亚硝基化是指将一氧化氮（nitric oxide,NO）衍生基团连接到半胱氨酸（cysteine,Cys）硫醇上生成S-亚硝基硫醇（S-nitrosothiol,SNO）的过程，其作为可逆的翻译后修饰有助于信号传导，在神经系统中参与多种生理和病理过程。该文将从S-亚硝基化的调节机制及其与神经系统性疾病发病过程和治疗的关系进行概述，以期为未来该类研究的发展提供一个新思路。更多还原

【Abstract】 Protein S-nitrosylation refers to the process of attaching a nitric oxide(NO)-derived group to a cysteine(Cys) thiol to generate S-nitrosothiol(SNO). S-nitrosylation is a reversible posttranslational modification,which acts a key role in the signal transduction pathway contributing to a variety of physiological and pathological processes in the nervous system. This article will summarize the regulatory mechanism of S-nitrosylation,its relationship with the pathogenesis,and the treatment of neurological diseases based on S-nitrosylation,in order to provide a new idea for the development of such research in the future.更多还原