【摘要】 目的 研究血清细胞粘合素C浓度对重型颅脑损伤（sTBI）患者住院期间死亡、外伤性脑梗死、急性创伤性凝血病、急性肺损伤和进展性出血性脑损伤等不良事件的预测价值。方法 选取102例sTBI患者，检测患者入院时血清细胞粘合素C浓度，采用格拉斯哥昏迷（GCS）评分和鹿特丹CT评分评估伤情程度，统计分析血清细胞粘合素C浓度对sTBI患者住院期间不良事件的预测价值。结果 血清细胞粘合素C浓度与sTBI患者入院时GCS评分和鹿特丹CT评分显著相关（均P<0.01），是sTBI患者住院期间不良事件的独立预测因素（均P<0.05），预测能力与入院时GCS评分和鹿特丹CT评分比较，差异均未有统计学意义（均P>0.05）。结论 sTBI患者血清细胞粘合素C浓度与伤情程度及临床预后密切相关，提示血清细胞粘合素C可能是sTBI潜在的预后标志物。更多还原

【Abstract】 Objective To investigate the predictive ability of serum tenascin-C concentrations for in-hospital adverse affairs, including mortality, posttraumatic cerebral infarction, acute traumatic coagulopathy, acute lung injury and progressive hemorrhagic injury in patients with severe traumatic brain injury(sTBI). Methods 102 patients with sTBI were enrolled. Serum tenascin-C concentration was measured. Glasgow coma scale(GCS) scores and Rotterdam CT scores were utilized to assess trauma severity. Statistical methods were used to assess the predictive value of serum Tenascin-C concentrations for in-hospital adverse affairs after sTBI. Results Serum tenascin-C concentrations were tightly correlated with GCS scores and Rotterdam CT scores(both P<0.01), and emerged as an independent predictor for in-hospital adverse affairs(all P<0.05) and there were no significant differences in terms of predictive capabilities between serum tenascin-C concentrations and GCS scores in addition to Rotterdam CT scores(all P>0.05). Conclusion Serum tenascin-C concentrations after sTBI are intimately correlated with trauma severity and clinical outcome, indicating serum tenascin-C may be a potential prognostic biomarker of sTBI.更多还原