【摘要】 目的：分析¹⁸F-FDG PET/CT代谢参数与非小细胞肺癌（non-small cell lung cancer,NSCLC）患者PD-L1表达的关系。方法：回顾性分析2019年3月至2021年7月于苏州大学附属第一医院行¹⁸F-FDG PET/CT显像的241例NSCLC患者临床资料，依据PD-L1表达状态分为阳性和阴性组、高表达和低表达组。Pearsonχ2检验比较组间分类变量的差异；t检验和Mann-Whitney U检验比较组间连续变量的差异。Logistic回归模型进行单因素和多因素分析。结果：在NSCLC中，PD-L1阳性组SUVmax、TLG均高于阴性组（P<0.05）。PD-L1高表达组SUVmax、MTV、TLG均高于低表达组（P<0.05）。鳞癌PD-L1阳性率、高表达率均高于腺癌（P<0.05）。在腺癌中，PD-L1阳性组、高表达组的SUVmax分别高于阴性组、低表达组（P<0.05），组间MTV、TLG差异无统计学意义（P>0.05）。在鳞癌中，代谢参数与PD-L1表达无明显相关性（P>0.05）。多因素分析表明，在NSCLC的腺癌中，SUVmax是PD-L1阳性的独立预测因素（P<0.05），也是PD-L1高表达的独立预测因素（P<0.05）。在ALK阴性腺癌中，SUVmax均是PD-L1阳性、高表达的独立预测因素（P<0.05）。结论：SUVmax能够预测腺癌患者PD-L1的表达状态，为免疫治疗提供依据。更多还原

【Abstract】 Objective: To investigate the relationship between metabolic parameters of ¹⁸F-fluorodeoxyglucose positron emission computed tomography(¹⁸F-FDG PET/CT) and the expression of programmed death-ligand 1（PD-L1） in patients with non-small cell lung cancer（NSCLC）.Methods: A total of 241 NSCLC patients who received preoperative ¹⁸F-FDG PET/CT were retrospectively enrolled in the present study at The First Affiliated Hospital of Soochow University from March 2019 to July 2021. In terms of the expression of PD-L1, patients were assigned into positive and negative groups, and high expression and low expression groups. A Chi-square test was used to analyze the difference between the two categorical variables, while a Mann–Whitney U test or t-test was used for the continuous variables. Multivariate analyses between the expression of PD-L1 and characteristics were analyzed by Logistic regression analysis. Results: In NSCLC, the SUVmax and TLG of the PD-L1 positive group were higher than those of the negative group（P<0.05）. SUVmax, MTV, and TLG in the PD-L1 high expression group were higher than those in the low expression group（P<0.05）. PD-L1 positive and high expression rates were higher in squamous carcinoma（SCC） than in adenocarcinoma（ADC）. In ADC, the SUVmax of PD-L1 positive and high expression groups were higher than those of the negative and low expression groups, respectively（P<0.05）. In SCC, there was no significant correlation between metabolic parameters and PD-L1expression（P>0.05）. Multivariate analysis revealed that SUVmax was an independent predictor of PD-L1 expression in NSCLC and ADC（P<0.05）, as well as in ALK-negative ADC. C onclusions: The SUVmax of ¹⁸F-FDG PET/CT was a predictor of PD-L1 expression in ADC. It had important clinical value in immunotherapy.更多还原