【摘要】 目的：验证冠状动脉造影血流储备分数（caFFR）在灰区的诊断准确度及其测量可重复性。方法：回顾性纳入进行经导丝血流储备分数（FFR）测定的冠心病患者150例，按照FFR的不同，分为灰区（FFR0.75～0.80）组（n=55）及非灰区（FFR<0.75或FFR>0.80）组（n=95）。由2名操作者独立使用FlashAngio系统进行caFFR离线测定。利用Pearson相关系数分析FFR与caFFR的相关性，Bland-Altman图示法分析FFR与caFFR的一致性以及2名操作者间的测量变异度，利用准确度、灵敏度、特异度等评价caFFR的诊断价值。结果：回顾性测量的caFFR与导丝FFR相关性（r=0.870,P<0.001）及一致性良好（差值均值为0.00,95%一致限：-0.08～0.09）。caFFR在灰区的诊断准确度稍有下降，但与非灰区相比差异无统计学意义（85.7%vs. 93.7%,P=0.089）。caFFR在不同操作者间的测量可重复性良好，平均差值为0.00(95%一致限：-0.12～0.13)。结论：caFFR在灰区的诊断准确度及不同观察者间测量一致性较好。更多还原

【Abstract】 Objectives: To verify the accuracy and reproducibility of coronary angiography-derived fractional flow reserve(caFFR)in grey zone and further demonstrate the application value of caFFR.Methods: One hundred and fifty patients with coronary artery disease who underwent flow reserve fraction(FFR)measurement were retrospectively included in this study and divided into grey zone group(FFR 0.75-0.80) and non-grey zone group(FFR<0.75 or FFR>0.80). caFFR was measured offline by two operators independently using the FlashAngio system.The correlation between FFR and caFFR was analyzed using the Pearson correlation coefficient, and the Bland-Altman graphical method was used to analyze the agreement between FFR and caFFR and the measurement variability between the two operators. The diagnostic value of caFFR was presented as percent of accuracy, sensitivity, and specificity.Results: The caFFR correlated(r=0.870, P<0.001) and agreed well with FFR(mean difference 0.00, 95% limits of agreement:-0.08 to 0.09). caFFR showed a slight decrease in diagnostic accuracy in the grey zone group, but was not significantly different from that of the non-grey zone group(85.7% vs. 93.7%, P=0.089). The measurement results of caFFR between different operators were reproducible, with a mean difference of 0.00(95% limits of agreement:-0.12 to 0.13).Conclusions: The diagnostic accuracy and reproducibility of caFFR in the grey zone are satisfactory.更多还原