【摘要】 目的 探讨甲状腺过氧化物酶抗体与围生期母婴结局的关系。方法 选取2016年5月至2018年5月于福建省妇幼保健院产检的孕13周前孕妇为研究对象，其中1 159例甲状腺过氧化物酶抗体阳性作为观察组，1 162例甲状腺过氧化物酶抗体阴性作为对照组。比较两组孕妇的妊娠合并症发生率及围生儿结局。结果 观察组孕妇的子宫肌瘤、妊娠合并糖尿病发生率高于对照组，胎膜早破发生率低于对照组，差异有统计学意义（P<0.05）；两组孕妇的贫血、血小板减少、妊娠期高血压疾病、急产发生率比较，差异无统计学意义（P>0.05）；观察组足月胎儿的出生体重重于对照组，孕妇的分娩孕龄长于对照组，早产发生率低于对照组，差异有统计学意义（P<0.05）；两组孕妇的胎盘重量比较，差异无统计学意义（P>0.05）。结论 甲状腺功能正常但甲状腺过氧化物酶自身抗体阳性的孕妇患妊娠合并糖尿病、子宫肌瘤风险增加，胎儿出生体重及分娩孕周增加。更多还原

【Abstract】 Objective To investigate the relationship between thyroid peroxidase antibody and perinatal maternal and infant outcomes. Methods From May 2016 to May 2018, pregnant women before 13 weeks of pregnancy in Fujian Maternal and Child Health Hospital were selected as the study objects, 1 159 cases with positive thyroid peroxidase antibody as the observation group, and 1 162 cases with negative thyroid peroxidase antibody as the control group. The incidence of pregnancy complications and perinatal outcomes were compared between the two groups. Results The incidence of hysteromyoma and pregnancy with diabetes in the observation group was higher than that in the control group, and the incidence of premature rupture of membranes was lower than that in the control group, with astatistically significant differences(P<0.05). There were no significant differences between the two groups in the incidence of anemia, thrombocytopenia, pregnancy induced hypertension, and emergency labor(P>0.05). The birth weight of the full-term fetus in the observation group was heavier than that in the control group, the gestational age of the pregnant women was longer than that in the control group, and the incidence of premature delivery was lower than that in the control group, the differences were statistically significant(P<0.05). There was no significant difference in placental weight between the two groups(P>0.05). Conclusion Pregnant women with normal thyroid function but positive thyroid peroxidase autoantibody have an increased risk of pregnancy complicated with diabetes, uterine leiomyoma, fetal birth weight and gestational weeks.更多还原