【摘要】 卵巢早衰（POF）通常是指女性在40岁以前出现卵巢功能减退甚至衰竭，临床上常表现为原发性或继发性闭经伴高促性腺激素水平及低雌激素水平，并伴有潮热盗汗、面部潮红、性欲低下等一系列低雌激素症状。此外，在POF患者中，心血管疾病、脑血管疾病、骨质疏松等疾病风险均增加，严重影响患者生活质量。近年来，POF的发病率逐年增加，严重危害患病女性的身心健康。POF病因复杂，大多数患者病因不明，可能与遗传性因素、自身免疫性因素、环境因素、医源性因素等相关。POF治疗棘手，目前，临床上最常应用激素替代治疗；另外，抗氧化剂、干细胞应用等也日渐成熟。经过查阅相关文献，本文从POF的病因及治疗研究进展等方面进行归纳总结，为今后进一步研究提供参考。更多还原

【Abstract】 Premature ovarian failure(POF) is the term usually to describe the cessation of ovarian function before the age of40. Clinically, it is often characterized by primary or secondary amenorrhea, elevated levels of gonadotropins, and low estrogen, accompanied by a series of low estrogen symptoms, such as hot flashes, night sweats, facial flushing, decreased sexual desire. In addition, the risk of cardiovascular disease, cerebrovascular disease, osteoporosis and other diseases increased among POF patients, which seriously affects the quality of life. Recently, the incidence of POF has increased yearly, seriously harming the physical and mental health of women with POF. The etiology of most POF cases is usually elusive, and maybe related to genetic factors, autoimmune factors, environmental factors, iatrogenic factors and so on. The treatment of POF is difficult. At preasent, hormone replacement therapy is most commonly used in clinical. And the application of antioxidants and stem cells is increasingly mature. After reviewing relevnt literature, this paper summarizes the etiology and treatment research progress of POF as a reference for future study.更多还原