【摘要】 目的 探讨复方甘草酸苷在巨细胞病毒（CMV）感染并肝损害患儿中的应用效果。方法 选取2020年7月至2021年7月江西省儿童医院收治的120例CMV感染并肝损害患儿作为研究对象，按照随机数字表法分为对照组（60例）与观察组（60例）。对照组采用更昔洛韦抗病毒联合还原型谷胱甘肽治疗，观察组在对照组基础上，加用复方甘草酸苷治疗。比较两组患儿的外周血CMV-DNA拷贝数、谷丙转氨酶（ALT）、谷草转氨酶（AST）、碱性磷酸酶（AKP）水平、淋巴细胞亚群水平（CD3~+、CD4~+、CD8~+及CD4~+/CD8~+）及不良反应发生情况。结果 两组患儿治疗前的CMV-DNA拷贝数、ALT、AST、AKP比较，差异无统计学意义（P>0.05）；观察组的CMV-DNA拷贝数、ALT、AST、AKP低于对照组，差异有统计学意义（P<0.05）。两组患儿治疗前的淋巴细胞亚群水平比较，差异无统计学意义（P>0.05）；观察组治疗后的CD3~+、CD8~+水平低于对照组，CD4~+、CD4~+/CD8~+水平高于对照组，差异有统计学意义（P<0.05）。观察组不良反应总发生率为3.33%，低于对照组的25.00%，差异有统计学意义（P<0.05）。结论 临床上CMV感染并肝损害患儿的治疗方法，施用基础治疗加复方甘草酸苷治疗措施，其治疗效果更好。更多还原

【Abstract】 Objective To investigate the efficacy of Compound Glycyrrhizin in children with cytomegalovirus(CMV) infection and liver damage. Methods A total of 120 children with CMV infection and liver damage admitted to Jiangxi Children′s Hospital from July 2020 to July 2021 were selected as the research objects and divided into control group(60 cases) and observation group(60 cases) according to the random number table method. The control group was treated with Ganciclovir Antiviral combined with Reduced Glutathione, and the observation group was treated with Compound Glycyrrhizin on the basis of the control group. The levels of CMV-DNA copy number, alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(AKP), lymphocyte subsets(CD3~+, CD4~+, CD8~+and CD4~+/CD8~+) in peripheral blood, and the incidence of adverse reactions were compared between the two groups. Results There were no significant differences in CMV-DNA copy number, ALT, AST and AKP between the two groups before treatment(P>0.05). The CMV-DNA copy number, ALT, AST and AKP in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). There were no significant differences in lymphocyte subsets between the two groups before treatment(P>0.05). After treatment, the levels of CD3~+and CD8~+in the observation group were lower than those in the control group, while the levels of CD4~+and CD4~+/CD8~+in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). The total incidence of adverse reactions in the observation group was 3.33%, which was lower than 25.00% in the control group, and the difference was statistically significant(P<0.05). Conclusion Basic treatment combined with Compound Glycyrrhizin is more effective in the treatment of CMV infection complicated with liver damage.更多还原