【摘要】 目的 探讨低流量吸氧对维持性血液透析（MHD）患者认知功能及生存质量的影响。方法 选取2020年3月至2021年6月在昌乐中医院及潍坊峡山医院门诊的62例MHD患者作为研究对象，依据随机抽签法分为治疗组（n=31）和对照组（n=31）。两组患者均接受每周3次、每次4 h的常规血液透析治疗，治疗组在血液透析过程中给予低流量吸氧4 h，对照组不做吸氧治疗。比较两组患者治疗前和治疗6个月后的蒙特利尔认知量表（Mo CA）评分、世界卫生组织生存质量测定量表简表（WHOQOL-BREF）评分。结果 治疗组治疗6个月后的Mo CA量表总分、视空间及执行能力、命名、注意、延迟回忆、定向子项评分均高于本组吸氧治疗前，差异有统计学意义（P<0.05）；治疗组治疗6个月后的Mo CA量表总分、视空间及执行能力、命名、抽象、注意、延迟回忆、定向子项评分均高于同期对照组，差异有统计学意义（P<0.05）。对照组治疗后的Mo CA量表总分、视空间及执行能力、注意、延迟回忆、定向子项评分均低于本组治疗前，差异有统计学意义（P<0.05）。治疗组患者吸氧治疗6个月后的WHOQOL-BREF各领域及总体感觉得分均高于治疗前及对照组，差异均有统计学意义（P<0.05）。结论 低流量吸氧能改善维持性血液透析患者的认知功能，提高生存质量。更多还原

【Abstract】 Objective To investigate the influence of low flow oxygen inhalation on cognitive function and quality of life in patients with maintenance hemodialysis(MHD). Methods A total of 62 outpatients with maintenance hemodialysis in Changle Traditional Chinese Medicine Hospital and Weifang Xiashan Hospital from March 2020 to June 2021 were selected as the research objects, and they were divided into the treatment group(n=31) and the control group(n=31) according to random lottery. Both groups received routine hemodialysis 3 times a week for 4 h each time. The treatment group was given low-flow oxygen inhalation for 4 h during hemodialysis, while the control group was not given oxygen inhalation. The scores of Montreal cognitive assessment scale(Mo CA), World Health Organization quality of life-BREF(WHOQOL-BREF) were compared between the two groups before treatment and after 6 months of treatment. Results The total score of Mo CA scale and the scores of visuospatial and executive ability, naming, attention, delayed recall and orientation sub items in the treatment group after 6 months of treatment were higher than those before the oxygen inhalation treatment, and the differences were statistically significant(P<0.05). The total score of Mo CA scale and the scores of visuospatial and executive ability, naming, abstraction, attention, delayed recall and orientation sub items in the treatment group after 6 months of treatment were higher than those in the control group at the same period, and the differences were statistically significant(P<0.05). The total score of Mo CA scale and the scores of visuospatial and executive ability, attention, delayed recall and orientation sub items of the control group after treatment were lower than those of the control group before treatment,and the differences were statistically significant(P<0.05). The WHOQOL-BREF scores in all fields and the overall sensory scores of the patients in the treatment group after 6 months of oxygen inhalation treatment were higher than those before treatment and in the control group, and the differences were statistically significant(P<0.05). Conclusion Low flow oxygen inhalation can improve cognitive function and quality of life in patients with maintenance hemodialysis.更多还原