【摘要】 目的 探讨康柏西普联合激光光凝治疗糖尿病性黄斑水肿的效果。方法 选取2020年6月至2021年5月景德镇市第二人民医院收治的120例糖尿病性黄斑水肿患者作为研究对象，采用随机数字表法将其分为对照组（60例，患眼60只）和观察组（60例，患眼60只）。对照组患者采用激光光凝治疗，观察组患者采用康柏西普联合激光光凝治疗。比较两组患者治疗前及治疗4个月后的黄斑区血流密度；比较两组患者治疗前及治疗1、2、4个月后的黄斑中心厚度、最佳矫正视力情况。结果 两组患者治疗4个月后的浅层视网膜、深层视网膜黄斑区血流密度均高于治疗前，且观察组患者治疗4个月后的浅层视网膜、深层视网膜黄斑区血流密度高于对照组，差异有统计学意义（P<0.05）；两组患者治疗1、2、4个月后的最佳矫正视力均高于治疗前，治疗2、4个月后的最佳矫正视力均高于治疗1个月后，治疗4个月后的最佳矫正视力均低于治疗2个月后，且观察组患者治疗1、2、4个月后的最佳矫正视力均高于对照组，差异有统计学意义（P<0.05）；两组患者治疗1、2、4个月后的黄斑中心厚度均低于治疗前，治疗2、4个月后的黄斑中心厚度均低于治疗1个月后，治疗4个月后的黄斑中心厚度均高于治疗2个月后，且观察组患者治疗1、2、4个月后的黄斑中心厚度均低于对照组，差异有统计学意义（P<0.05）。结论 康柏西普联合激光光凝治疗糖尿病性黄斑水肿，可有效缓解患者的临床症状，抑制黄斑中心厚度增加，提高视功能，且疗效显著。更多还原

【Abstract】 Objective To explore the effect of Conbercept combined with laser photocoagulation in the treatment of diabetic macular edema. Methods A total of 120 patients with diabetic macular edema who were admitted to Jingdezhen Second People′s Hospital from June 2020 to May 2021 were selected as the research subjects, and they were divided into the control group(60 patients, 60 eyes) and the observation group(60 patients, 60 eyes) by the random number table method. The control group was treated with laser photocoagulation, and the observation group was treated with Conbercept combined with laser photocoagulation. The blood flow density in macular area was compared between the two groups before and after 4 months of treatment. Macular center thickness and best corrected visual acuity were compared between the two groups before treatment and 1, 2 and 4 months after treatment. Results After 4 months of treatment, the blood flow density in the superficial and deep macular areas of the two groups were higher than those before treatment, and the blood flow density in the superficial and deep macular areas in the observation group after 4 months of treatment were higher than those in the control group, the differences were statistically significant(P<0.05). The best corrected visual acuity levels of the two groups at 1, 2 and 4 months after treatment were higher than those before treatment, the best corrected visual acuity levels of the two groups after 2 and 4 months of treatment were higher than those after 1 month of treatment, the best corrected visual acuity levels after 4 months of treatment of the two groups were lower than those after 2 months of treatment, the best corrected visual acuity levels of observation group after 1, 2 and4 months of treatment were higher than those in the control group, and the differences were statistically significant(P<0.05). The thickness of macular center levels in the two groups after 1, 2 and 4 months of treatment were lower than those befo re treatment, the thickness of macular center levels in the two groups after 2 and 4 months of treatment were lower than those after 1 month of treatment, the thickness of macular center levels in the two groups after 4 months of treatment were lower than those after 2 months of treatment, the thickness of macular center levels of observation group after 1, 2 and 4 months of treatment were lower than those in the control group, and the differences were statistically significant(P<0.05). Conclusion Combined with laser photocoagulation, Conbercept can effectively relieve the clinical symptoms of diabetic macular edema, inhibit the increase of macular center thickness and improve visual function, and has a significant therapeutic effect.更多还原