【摘要】 目的 探讨α-硫辛酸（AL）升高血清硫化氢（H₂S）水平改善糖尿病周围神经病变(DPN的机制。方法 选取2019年1～12月于河北医科大学第三医院内分泌科住院的T2DM患者231例，分为单纯T2DM组（T2DM,n=109）和合并DPN组（DPN,n=122）。DPN组再分为常规治疗亚组（Con,n=64）和AL治疗亚组（AL,n=58）。检测各组血清H₂S水平及相关生化指标，进行神经系统症状评分（NSS）和密歇根糖尿病神经病变评分（MDNS），测量感觉神经传导速度（SCV）、运动神经传导速度（MCV）。结果DPN组血清H₂S水平低于T2DM组[3.67（3.01,4.57）vs 4.00（3.32,5.11）μmol/L,P=0.016]。Spearman相关分析显示，DPN患者血清H₂S水平与SCV、MCV呈正相关（P<0.05），与NSS、MDNS呈负相关，（P<0.05）。AL治疗2周后，AL亚组血清H₂S水平变化值高于Con亚组[0.96（0.24,2.13）vs 0.34（0.08,0.93）μmol/L,P=0.001]。结论 AL可通过升高DPN患者血清H₂S水平改善临床症状。更多还原

【Abstract】 Objective To explore whether alpha-lipoic（AL）acid ameliorates diabetic peripheral neuropathy（DPN）by elevating serumhydrogen sulfide（H₂S）level.Methods 231 in patients with type2 diabetes mellitus（T2DM）in Third Hospital of Hebei Medical University from January 2019 to December2019 were recruited in this study and divided into T2DM group（T2DM,n=109）and DPN group（n=122）.The DPN group was split into conventional therapy subgroup（Con,n=64）and AL subgroup（AL,n=58）.Serum H₂S level and other correlated biochemical indexes were measured. Neuropathy symptom score（NSS）and Michigan diabetic neuropathy score（MDNS）were evaluated. Sensory/motor nerve conduction velocity（SCV/MCV）were detected.Results The serum H₂S level of DPN group was lower than that of T2DM group[3. 67（3. 01,4. 57）vs 4. 00（3. 32,5. 11）μmol/L,P=0. 016]. Spearman correlation analysis showed that serum H₂S in patients with DPN was positively correlated with SCV and MCV（P<0. 05）,and negatively correlated with NSS and mDNS（P<0. 05）. After two weeks treatment,the increment of serum H₂S level in AL subgroup was higher than that in Con subgroup[0. 96（0. 24,2. 13）vs 0. 34（0. 08,0. 93）μmol/L,P=0. 001].Conclusion AL could alleviate DPN by elevating serum H₂S level.更多还原