【摘要】 目的：探讨黑小麦粉对高脂血症大鼠血脂的调节作用及肝肾功能的影响，为高脂血症的合理饮食奠定基础。方法：50只大鼠按体重随机被分为5组，每组10只。对正常对照组大鼠饲喂标准饲料，其余4组大鼠饲喂高脂饲料诱导血脂异常。高脂血症大鼠分为模型对照组、黑小麦高剂量组、中剂量组和低剂量组。连续饲养6周，检测大鼠血脂、体重等，观察肝脏、肾脏病理切片。结果：1）黑小麦不同剂量组大鼠体重增加均显著低于正常对照组，并且高剂量组显著低于模型对照组。2）黑小麦各组大鼠的血脂水平显著降低，且TC和LDL低于模型对照；不同剂量组间血脂水平无明显差异。3）病理检测表明，与模型对照相比，黑小麦各组肝细胞脂肪变性程度较低，肾组织病变减轻。结论：黑小麦粉能减轻大鼠体重，改善大鼠脂代谢紊乱，减轻高脂血症对肝脏、肾脏损伤。更多还原

【Abstract】 Objective: The purpose of the study was to explore the effects of black wheat flour on hypolipidemic action,liver and kidney function of rat with hyperlipidemia, so as to lay the foundation of a dietary therapy for hyperlipidemia.Methods: A total of 50 rats were randomly divided into five groups according to their body weight, 10 rats in each group. The normal control group rats were fed with a standard diet, whereas the other four groups of rats were fed with a high-fat diet to induce dyslipidemia. Hyperlipidemia rats were randomly divided into dyslipidemia control group(DC)and black wheat flour high dose group, middle dose group and low dose group. Rats were fed with corresponding food for 6 weeks, blood lipid levels and body weight of the rats were detected, and the pathological sections of the liver and kidney tissues were observed. Results: 1) The weight-gain-ratio of all dose groups rats were significantly lower than that of the control group rats, and it was significantly lower in black wheat high dose group when compared to the DC group.2) Compared with before dietary intervention, the blood lipid levels of rats in the three dose groups were significantly reduced, and TC and LDL were lower than that of the DC group, all dose groups serum levels is no statistically difference. 3) The pathological examination showed that the hepatocyte steatosis was at lower level, and renal lesion was alleviated in black wheat all dose groups, compared to the DC. Conclusions: Black wheat flour can lighten the weight of hyperlipidemia rats, ameliorate the lipid metabolism disorder effectively, alleviate the liver and kidney injury caused by hyperlipidemia.更多还原