【摘要】 目的探讨国际妇产科联盟(FIGO)2018分期ⅠA～ⅡA期子宫颈癌患者术后辅助治疗的规范性对肿瘤学结局的影响。方法在中国子宫颈癌临床诊疗项目大数据库中筛选FIGO 2018ⅠA～ⅡA期接受规范手术治疗的子宫颈癌患者,比较术后治疗规范与术后治疗不规范患者的5年总体生存率(OS)和无瘤生存率(DFS)。结果 (1)纳入符合入组标准的FIGO 2018ⅠA～ⅡA期接受规范手术治疗5638例(包括术后治疗规范2205例,术后治疗不规范3433例),中位随访时间44个月(术后治疗规范组43个月,术后治疗不规范组46个月)。(2)Kaplan-Meier生存分析显示,术后治疗规范组肿瘤学结局明显优于术后治疗不规范组(OS:95.7%vs. 88.7%,P<0.001;DFS:92.1%vs.83.4%,P<0.001)。(3)Cox多因素分析显示,术后治疗不规范组发生死亡的风险是术后治疗规范组的1.556倍(HR=1.556,95%CI 1.135～2.133,P=0.006),发生复发/死亡的风险是术后治疗规范组的1.391倍(HR=1.391,95%CI1.113～1.737,P=0.004)。结论从肿瘤学预后分析,术后治疗规范患者肿瘤学结局优于术后治疗不规范者,故术后治疗规范性需要得到重视。更多还原

【Abstract】 Objective To explore the effect of standardization of postoperative adjuvant therapy on oncology outcome in patients with FIGO 2018 stage I A-II A cervical cancer.Methods Patients with cervical cancer in the new stage I AII A of FIGO 2018 were selected from Four C Database.The 5-year OS and DFS of patients with standardized and nonstandardized postoperative treatments were compared.Results(1)Totally 5638 patients with cervical cancer were in FIGO 2018 stage Ⅰ A-Ⅱ A enrolled(standardized postoperative treatment 2205,non-standardized postoperative treatment 3433).The median follow-up period was 44 months(standardized postoperative treatment 43 months,nonstandardized postoperative treatment 46 months).(2) Kaplan-Meier survival analysis showed that the oncology outcome of the standardized postoperative treatment group was significantly better than that of the non-standardized postoperative treatment group(OS:95.7% vs.88.7%,P <0.001;DFS:92.1% vs.83.4%,P <0.001).(3) Cox multivariate analysis showed that the risk of death in the non-standardized postoperative treatment group was 1.556 times higher than that in the standardized postoperative treatment group(HR=1.556,95%CI 1.135-2.133,P=0.006),and the risk of recurrence/death was 1.391 times higher(HR=1.391,95%CI 1.113-1.737,P=0.004).Conclusion From the perspective of oncology outcome,the oncology outcome of the standardized postoperative treatment group is better than that of the non-standardized postoperative treatment group.The standardization of postoperative treatment needs to be paid attention to.更多还原