【摘要】 本文选取典型石化城市茂名市某石化工业园30名员工（男女各15名）进行裸露（额头、手掌）和遮蔽皮肤部位（前臂、小腿）的擦拭采样,通过气相色谱-质谱联用仪（GC-MS）测定了擦拭样品中15种多环芳烃的浓度(∑₁₅PAHs)并计算了经皮肤暴露和手-口接触的人体暴露剂量.结果表明,皮肤样品中∑₁₅PAHs的浓度范围为21～1.9×10⁴ng/m²,不同部位间PAHs浓度存在显著性差异（P<0.01）,表现为额头>手掌>前臂>小腿.PAHs以3～4环PAHs组成为主.男女性别间PAHs组成无显著差异,∑₁₅PAHs女性高于男性,但无统计差异性.经皮肤吸收的PAHs日暴露剂量（DADderm）女性[41ng/（kg·d）]显著高于男性[28ng/（kg·d）].手-口接触暴露剂量[0.34ng/（kg·d）]相比于皮肤暴露剂量[34ng/（kg·d）]可忽略不计.皮肤暴露剂量主要来自裸露部位皮肤的贡献（88%）.风险评价结果表明,PAHs的皮肤暴露和手-口接触暴露不存在明显的非致癌风险;但约7%员工的皮肤致癌风险高于可接受的水平(10^-4),表明存在一定的PAH致癌风险.更多还原

【Abstract】 In the study, skin wipe samples were collected from four typical skin parts（forehead, palm, forearm and shank） of 30volunteers（15 men and 15 women）, who work in a Petrochemical Industrial Park in Maoming City（a typical petrochemical city）.The concentrations of 15 polycyclic aromatic hydrocarbons(∑₁₅ PAHs) in wiping samples were determined by gas chromatography-mass spectrometry（GC-MS）, and the human exposure doses through skin exposure and hand-mouth contact were calculated. The concentration of Σ₁₅PAHs in skin samples ranged from 21 to 1.9×10⁴ng/m². The PAH concentrations exhibited significant differences among different skin parts（P<0.01） with the order of forehead > palm > forearm > shank. PAHs are mainly composed of 3～4rings. Although no statistical difference was observed in ∑₁₅ PAHs between female and male, the daily dermal absorption doses of PAH（DADderm） was significantly higher in female [41ng/（kg·d）] than male [28ng/（kg·d）]. The hand-mouth exposure dose [0.34ng/（kg·d）] was negligible to compare with the dermal absorption dose [34ng/（kg·d）]. The bared skins contribute to 88% of dermal absorption dose. There was no obvious non-carcinogenic risk but risks of skin cancer were higher than the acceptable level(1×10^-4) for 7% staff, indicating potential skin cancer risk.更多还原