【摘要】 缺血性脑血管病(ischemic cerebrovascular disease, ICVD)是常见的中枢神经系统疾病，具有较高的发病率和死亡率。脑侧支循环对常由动脉粥样硬化所致的ICVD具有良好的代偿作用。近年来有研究显示，miRNA在脑血管动脉粥样硬化及其侧支循环建立的多种生理、病理过程中发挥重要作用，具有作为ICVD疾病诊断和病情评估的新型生物标志物的潜力。本文就miRNA与ICVD脑血管动脉粥样硬化及其侧支循环建立的相关性作一综述。更多还原

【Abstract】 Ischemic cerebrovascular disease(ICVD) is a common central nervous system disease with high morbidity and mortality. Cerebral collateral circulation has a positive compensatory effect on ICVD, which is often caused by atherosclerosis. In recent studies, various physiological and pathological processes of cerebrovascular atherosclerosis and establishment of collateral circulation were closely related to miRNA that has the potential to be used as a new biomarker for diagnosis and evaluation of ICVD. This article reviews the relationship between miRNA and cerebrovascular atherosclerosis, and the establishment of collateral circulation in ICVD.更多还原