【摘要】 目的 对药物过量使用性头痛（Medication Overuse Headache,MOH）患者临床特征和神经心理学特点进行研究。方法 纳入2017年9月～2018年11月就诊于南京医科大学第一附属医院神经内科头痛专病门诊的MOH及发作性偏头痛（Episodic Migraine,EM）患者各30例，另选取健康对照者30例，分析MOH的头痛特征和过量使用药物情况，采用医院焦虑抑郁量表（Hospital Anxiety and Depression Scale,HADS）、匹兹堡睡眠质量指数量表（Pittsburgh sleep quality index, PSQI）、利兹依赖问卷（Leeds Dependence Questionnaire,LDQ）对所有入组人群的神经心理学特点进行评估和比较。结果 MOH患者最常使用复方止痛药。MOH组焦虑、抑郁、PSQI、LDQ评分均显著高于健康对照组（P <0.001）和EM组（P <0.001），而EM组和健康对照组在神经和心理学量表评估得分上差异无统计学意义。结论 MOH患者常共患焦虑、抑郁、睡眠障碍，且有药物依赖的特点，慢性头痛、焦虑抑郁、睡眠障碍及药物依赖常常互为因果，临床医生需充分识别评估MOH患者的精神心理状况，给予综合性治疗，以提高疗效。更多还原

【Abstract】 Objective To investigate the clinical and neuropsychological characteristics of patients with medication overuse headache(MOH). Methods 30 patients with MOH and 30 episodic migraine(EM) patients were enrolled in the headache clinic of the Department of Neurology, the First Affiliated Hospital of Nanjing Medical University from September 2017 to November 2018. Another 30 healthy subjects were included as the control group. Headache characteristics and drug overdose of MOH patients were analyzed. The Hospital Anxiety and Depression Scale(HADS), Pittsburgh sleep quality index(PSQI), and Leeds Dependence Questionnaire(LDQ) were used to evaluate and compare the neuropsychological characteristics of all enrolled populations. Results Compound analgesics were the most frequently overused medications in patients with MOH. The scores of anxiety, depression, PSQI and LDQ in the MOH group were significantly higher than those in the healthy control group(P < 0.001) and the EM group(P < 0.001), but there was no significant difference between the EM group and the healthy control group in the evaluation of the neuropsychology scales. Conclusion Patients with MOH often suffer from anxiety, depression and sleep disorders, and have the characteristics of drug dependence. They are often causative to each other. Physicians need to fully identify and evaluate the mental and psychological status of MOH patients and give comprehensive treatment to improve the efficacy.更多还原