【摘要】 目的 探讨原发性卵巢淋巴瘤（primary ovarian lymphoma,POL）患者的临床特点及预后因素。方法 收集2000～2017年美国国家癌症研究所监测、流行病学和最终结局（surveillance, epidemiology, and end results,SEER）数据库中病理确诊为POL的136例成年患者的临床资料。采用Kaplan–Meier法绘制生存曲线，Log–Rank检验比较组间患者生存率差异，采用Cox比例风险回归模型分析POL患者预后的影响因素。结果 POL患者中位年龄48.5(19～92)岁，中位生存时间未达到，弥漫大B细胞淋巴瘤和滤泡性淋巴瘤占比较高，分别为95例（69.9%）和16例（11.8%）。多因素分析结果显示，年龄≥60岁、Ann Arbor分期为Ⅳ期、肿瘤累及双侧卵巢、采用放疗均是影响POL患者总生存的独立危险因素（均P<0.05），除黑种人和白种人外的其他人种、Ann Arbor分期为Ⅳ期、肿瘤累及双侧卵巢均是影响POL患者肿瘤特异性生存的独立危险因素（均P<0.05）。结论 年龄、Ann Arbor分期、肿瘤是否累及双侧卵巢、是否放疗、种族均与POL患者的预后独立相关。更多还原

【Abstract】 Objective To investigate the clinical features and prognostic factors of primary ovarian lymphoma(POL).Methods The clinical data of 136 adult patients with pathologically confirmed POL from 2000 to 2017 were collected from the surveillance, epidemiology, and end results(SEER) database of the National Cancer Institute. Kaplan–Meier method was used to draw survival curves, and the difference in survival rate was compared using the Log–Rank test,multivariable Cox regression analysis was used to analyze prognostic factors of POL patients. Results The median age of the whole group was 48.5(19–92) years, and the median survival time was not reached. Diffuse large B cell lymphoma and follicular lymphoma accounted for 95 cases(69.9%) and 16 cases(11.8%), respectively. Multivariate analysis showed that age ≥60 years, Ann Arbor stage Ⅳ, bilateral ovarian tumor involvement, and radiotherapy were independent risk factors affecting overall survival of POL patients(all P<0.05). Race other than black and white,Ann Arbor stage Ⅳ, and bilateral ovarian tumor involvement were independent risk factors for cancer special survival of POL patients. Conclusion Age, Ann Arbor stage, whether bilateral ovarian involvement, radiotherapy, and race were independently associated with the prognosis of POL patients.更多还原