【摘要】 目的 探究维持性血液透析患者的中性粒细胞/淋巴细胞比值（NLR）与心血管疾病的关系。方法 回顾性分析2018年9月～2021年8月于湖北省十堰市太和医院接受治疗的维持性血液透析患者的诊疗情况，选取193例作为维持性血液透析组，并选择同期接受体检的健康志愿者60名作为对照组。根据患者情况将维持性血液透析组分为心血管疾病组及非心血管疾病组。比较各组的性别、年龄、血钙（Ca）、血磷（P）、血红蛋白（Hb）、白蛋白（Alb）、高敏C-反应蛋白（hs-CRP）、中性粒细胞数量、淋巴细胞数量及NLR，分析其对维持性血液透析患者合并心血管疾病的影响。结果 维持性血液透析组的Ca、Hb、Alb、淋巴细胞数量均低于对照组，P、hs-CRP、中性粒细胞数量、NLR均高于对照组，差异有统计学意义（均P<0.05）。心血管疾病组的年龄、Ca、P、hs-CRP、中性粒细胞数量、NLR均高于非心血管疾病组，Hb、Alb、淋巴细胞数量均低于非心血管疾病组，差异有统计学意义（均P<0.05）。经Logistic回归分析发现，年龄、Hb、Alb及NLR均是影响维持性血液透析患者合并心血管疾病的危险因素（均P<0.05）。结论 维持性血液透析患者的NLR呈升高状态，是影响心血管疾病发生的独立危险因素。更多还原

【Abstract】 Objective To explore the relationship between the neutrophil to lymphocyte ratio(NLR) and cardiovascular disease in patients undergoing maintenance hemodialysis. Methods The diagnosis and treatment conditions of the patients undergoing maintenance hemodialysis in Taihe Hospital in Shiyan in Hubei Province from September 2018 to August 2021 were retrospectively analyzed. A total of 193 patients were selected as the maintenance hemodialysis group, and 60 healthy volunteers who underwent physical examination in the same period were selected as the control group. According to the conditions of patients, the maintenance hemodialysis group was subdivided into the cardiovascular disease group and the non-cardiovascular disease group. Gender, age, blood calcium(Ca), blood phosphorus(P),hemoglobin(Hb), albumin(Alb), high-sensitivity C-reactive protein(hs-CRP), neutrophil count, lymphocyte count and NLR were compared among the groups. Its effects on cardiovascular disease in patients undergoing maintenance hemodialysis were analyzed. Results The levels of Ca, Hb and Alb and lymphocyte count in the maintenance hemodialysis group were lower than those in the control group, and the levels of P and hs-CRP, neutrophil count and NLR were higher than those in the control group, with statistically significant differences(all P<0.05). The age, the levels of Ca, P and hs-CRP, neutrophil count and NLR in the cardiovascular disease group were higher than those in the non-cardiovascular disease group, and the levels of Hb and Alb and lymphocyte count were lower than those in the non-cardiovascular disease group, with statistically significant differences(all P<0.05). Logistic regression analysis showed that age, Hb, Alb and NLR were the risk factors for cardiovascular disease in patients undergoing maintenance hemodialysis(all P<0.05). Conclusion NLR in patients undergoing maintenance hemodialysis is elevated and is an independent risk factor for cardiovascular disease.更多还原