【摘要】 目的 比较两种促排卵药物在促性腺激素释放激素激动剂（GnRH-a）长方案中的应用，探讨其对辅助生殖（ART）患者助孕结局的影响。方法 回顾性分析2019年4月至2020年6月于枣庄市妇幼保健院生殖医学中心IVF-ET/ICSI-ET长方案助孕患者新鲜周期的临床资料共374周期，按照其应用外源性促性腺激素药物（Gn）的不同分为两组：使用国产重组人促卵泡激素（r-hFSH，金赛恒）进行控制性超促排卵（COH）176周期（A组），使用进口重组人促卵泡素β（r-hFSH，普利康）进行COH198例（B组）。分别比较两组患者的一般情况、用药情况、实验室各指标及最终临床结局。结果 两组患者的平均年龄、平均不孕年限、体质量指数（BMI）、抗苗勒试管激素（AMH）值、基础卵泡刺激素（b-FSH）值等比较，差异均无统计学意义（P>0.05）；两组Gn量、Gn天数、HCG日子宫内膜的厚度、受精率、可移植胚胎率、优质胚胎率、无可移植胚胎周期率、移植胚胎数、妊娠率、着床率、早期流产率等比较，差异均无统计学意义（P>0.05）;B组患者较A组患者有更多的获卵数[（13.78±4.37）枚vs.（10.41±3.87）枚]，差异有统计学意义（P<0.05）。结论 在GnRH-a长方案超促排卵中，应用国产重组人促卵泡激素注射液和进口重组促卵泡素β注射液均可以获得满意的临床结局。更多还原

【Abstract】 Objective To observe and compare the application of two kinds of ovulation induction drugs in gonadotropin-releasing hormone agonist（GnRH-a） long protocol and explore its effect on assisted pregnancy outcomes in patients with assisted reproductive technology（ART）. Methods The clinical data of 374 fresh IVF-ET/ICSI-ET long protocol assisted pregnant patients in the Reproductive Medicine Center of Maternity and Child Health Care of Zaozhuang from April 2019 to June 2020 retrospectively analyzed and divided into two groups according to their application of exogenous gonadotropins（Gn）.Domestic recombinant human follicle-stimulating hormone（r-hFSH）（Jinsaiheng） was used for 176 cycles of controlled ovarian hyperstimulation（COH）（ group A）.Imported recombinant human follicle-stimulating hormone β（r-hFSH）（Plikang） was used for COH in 198 cases（group B）.The general conditions, medication, laboratory parameters, and final clinical outcomes of patients in two groups were compared.Results There was no significant difference in the mean age,mean duration of infertility, body mass index（BMI）,antiMullerian hormone（AMH） value,and basal follicle-stimulating hormone（b-FSH） value between group A and group B（P >0.05）. There was no significant difference in Gn amount, Gn days,endometrial thickness on HCG day,fertilization rate, transferable embryo rate,high-quality embryo rate,non-transferable embryo cycle rate, number of transferred embryos, pregnancy rate,implantation rate, and early abortion rate（P >0.05）. Patients in group B had more oocytes（[13.78±4.37] Pieces vs. [10.41±3.87] Pieces） than those in group A,and the difference was statistically significant（P<0.05）. Conclusion Both domestic recombinant human follicle-stimulating hormone injection and imported recombinant follicle-stimulating hormone β injection in long protocol GnRH-a ovarian hyperstimulation can obtain satisfactory clinical outcomes.更多还原