【摘要】 目的 分析妊娠晚期牙周病孕妇血清和胎盘组织中的肿瘤坏死因子-α浓度对妊娠结局所产生的影响。方法 选取2019年1月至2020年6月在福州市第一医院产科门诊规范产检的81例孕妇为研究对象，根据患病与否分为牙周病53例（患病组），牙周正常者28例（健康组），检测所有孕妇孕晚期血清和胎盘组织中的肿瘤坏死因子-α浓度，并严密跟踪妊娠并发症和新生儿预后。结果 患病组孕妇的血清肿瘤坏死因子-α浓度平均值为（33.93±15.02）pg/ml，高于健康组的（27.10±11.41）pg/ml，差异有统计学意义（P<0.05），患病组孕妇胎盘组织中的肿瘤坏死因子-α浓度平均值为（44.75±10.85）pg/ml，高于健康组的（38.96±11.11）pg/ml，差异有统计学意义（P<0.05）；患病组的并发症发生率（69.81%）远高于健康组（39.29%），差异有统计学意义（P<0.05），患病组的妊娠期糖尿病发生率（39.62%）高于健康组（17.86%），差异有统计学意义（P<0.05），患病组的新生儿并发症发生率（39.62%）高于健康组（14.29%），差异有统计学意义（P<0.05）。结论 牙周病患者的母婴结局较健康组差，可能与肿瘤坏死因子-α浓度有关。更多还原

【Abstract】 Objective To analyze the effect of tumor necrosis factor-α concentration in serum and placental tissue of pregnant women with periodontal disease in the third trimester of pregnancy on pregnancy outcomes. Methods A total of 81 pregnant women who underwent a standardized prenatal examination in Department of Obstetrics, Fuzhou First Hospital from January 2019 to June 2020 were selected as the study subjects and divided into periodontal disease group(n=53) and periodontally normal group(n=28) according to the presence or absence of the disease. Serum and placental tissue tumor necrosis factor-α concentrations were measured in the third trimester of pregnancy in all pregnant women. The pregnancy complications and neonatal prognosis were closely followed up. Results The results showed that the mean serum tumor necrosis factor-α concentration in the diseased group([33.93±15.02]pg/ml) was higher than that([27.10±11.41]pg/ml) in the healthy group, and the difference was statistically significant(P<0.05). The mean placental tissue tumor necrosis factor-α concentration in the diseased group([44.75 ±10.85]pg/ml) was higher than that([38.96±11.11]pg/ml) in the healthy group, and the difference was statistically significant(P <0.05). The incidence of complications in the diseased group(69.81%) was much higher than that(39.29%) in the healthy group, and the difference was statistically significant(P<0.05). The incidence of gestational diabetes in the diseased group(39.62%) was higher than that(17.86%) in the healthy group, and the difference was statistically significant(P<0.05). The incidence of neonatal complications in the diseased group(39.62%) was higher than that(14.29%) in the healthy group, and the difference was significant(P<0.05). Conclusion The maternal and fetal outcomes of patients with periodontal disease are worse than those of healthy groups, which may be related to tumor neorosis factor-α concentration.更多还原