【摘要】 目的 探讨夫精宫腔内人工授精（IUI）临床妊娠率的相关影响因素，以期为提高IUI妊娠率提供参考。方法 回顾性分析2018年4月至2022年1月在莆田学院附属医院生殖医学中心进行IUI治疗的1 097个周期的临床资料。比较分析女方年龄、不孕类型、不孕年限、体质量指数（BMI）、不孕因素以及周期相关因素，探讨各种因素与临床妊娠率的关系。结果 根据年龄、不孕因素及优势卵泡数分组，各组间的临床妊娠率差异有统计学意义（P <0.05）。多因素Logistic回归分析显示，女方年龄、不孕因素及优势卵泡个数是影响IUI妊娠率的独立因素。随着年龄的增大，IUI妊娠率逐渐降低。不孕因素中，性功能障碍、排卵障碍及少弱精组的妊娠概率分别是不明原因组的2.825倍、2.126倍及1.9倍。2～3个优势卵泡数组的妊娠概率是1个优势卵泡组的1.717倍。结论 女方年龄、不孕因素及优势卵泡个数是IUI妊娠率的主要影响因素。临床可综合患者的实际情况进行针对性干预，以期改善妊娠结局。更多还原

【Abstract】 Objective To discuss the factors affecting the clinical pregnancy rate of intrauterine insemination with husband’s sperm, then to provide reference for improving IUI pregnancy rate. Methods The clinical data of 1097 cycles of IUI treatment at Reproductive Medicine Center of Affiliated Hospital of Putian University from April 2018 to January 2022 were retrospectively analyzed. Women’s age, infertility type, infertility years, body mass index(BMI), infertility factor and cycle related factors were analyzed. Then explore the relationship between various factors and clinical pregnancy rate. Results Grouped according to the age, infertility factors and the number of dominant follicles, the difference in clinical pregnancy rate among groups was statistically significant(P<0.05). Multivariate Logistic regression analysis showed that female age, infertility factors and number of dominant follicles were independent factors affecting IUI pregnancy rate. With the increase of age,IUI pregnancy rate gradually decreased.Among infertility factors, the pregnancy probability of sexual dysfunction, ovulation disorder and oligospermia group was 2.825 times, 2.126 times and 1.9 times higher than that of unknown cause group, respectively. The pregnancy rate of 2 to 3 dominant follicles was 1.717 times higher than that of 1 dominant follicle group. Conclusion Female age, infertility factor and number of dominant follicles were the main influencing factors of IUI pregnancy rate. Specific intervention can be carried out according to the actual situation of patients to improve pregnancy outcomes.更多还原