【摘要】 目的了解我国真实世界研究领域研究现状和研究热点。方法检索PubMed、Embase(Ovid)、CENTRAL(Ovid)、中国知网、维普、万方和中国生物医学数据库,搜集中国学者发表的真实世界研究文献,检索时限均从建库至2020年6月11日。由2名研究者独立筛选文献,利用书目共现分析系统BICOMB 2.0提取和统计文献信息,运用图形聚类工具包gCLUTO聚类分析关键词。结果最终纳入中国学者发表的真实世界研究文献1612篇,总体发文量呈递增趋势,发文期刊638种,发文量较多机构包括中国中医科学院中医临床基础医学研究所、中国人民大学、中国人民解放军海军总医院等。研究热点问题广泛,涉及中药和中医证候研究,药物临床应用过程中的安全性和不良反应研究,心脑血管疾病风险因素、治疗措施和临床结局等主题。结论真实世界研究在国内起步晚但发展迅速,研究热点问题广泛。更多还原

【Abstract】 Objective To analyze the research status and focus in Chinese real-world study. Methods The data bases of PubMed, EMBASE（Ovid）,CENTRAL（Ovid）,CNKI,VIP,Wanfang,and SinoMed were searched to collect real-world studies published by Chinese scholars from inception to 11^th June 2020.Two researchers independently screened the literature, extracted and counted information by BICOMB 2.0 and clustering analysis was performed by CLUTO. Results Eventually, 1612 real-world studies published by Chinese scholars were included.The number of articles is generally increasing, including 638 journals. Most articles are published from several institutions, including the Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences, Renmin University of China, the Sixth Medical Center of PLA General Hospital, etc.There are a wide range of research issues, including Chinese materia medica and syndromes, safety and adverse reactions in the drug clinical application, risk factors, treatment measures and clinical outcomes of cardiovascular and cerebrovascular diseases. Conclusion Rea-world study sprang up lately but developed rapidly in China, with extensive research issues.更多还原