【摘要】 目的 探讨输尿管软镜下钬激光碎石取石术后患者并发尿脓毒血症的影响因素。方法 选取杭州市中医院泌尿科2019年2月至2020年3月收治的400例输尿管结石患者作为观察对象，依据是否并发尿脓毒血症分为未发生组（310例）和发生组（90例）。比较两组性别、年龄、高血压、体重指数、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、手术时间、结石数量、结石直径、血肌酐、尿素氮、C反应蛋白、降钙素原情况。logistic回归分析输尿管软镜下钬激光碎石取石术后患者并发尿脓毒血症的影响因素。结果 两组年龄、性别、结石数量、结石直径、手术时间、血肌酐、尿素氮、C反应蛋白、降钙素原比较，差异有统计学意义（P <0.05）。患者多发结石、结石直径≥20 mm、血肌酐、尿素氮、C反应蛋白、降钙素原均是输尿管软镜下钬激光碎石取石术术后并发尿脓毒血症的影响因素（OR> 1,P <0.05）。结论 多发结石、结石直径≥20 mm、血肌酐、尿素氮、C反应蛋白、降钙素原是术后并发尿脓毒血症的影响因素，积极采取干预对降低术后并发尿脓毒血症发生具有积极意义。更多还原

【Abstract】 Objective To explore influencing factor of urinary sepsis in patients undergoing retrograde intrarenal surgery under flexible ureteroscope. Methods A total of 400 ureteral calculi patients in Hangzhou Hospital of Traditional Chinese Medicine from February 2019 to March 2020 were selected as objects, they were divided into non-occurrence group(310 cases), occurrence group(90 cases) by complicating urinary sepsis or not. The sex, age, hypertension, body mass index, triglyceride, high density liptein cholesterol, fasting blood glucose, operation time, calculi number,diameter, serum creatinine, blood urea nitrogen, C-reactive protein, procalcitonin of patients were compared. Logistic regression analysis was used to analyze the influencing factors of urinary sepsis in patients after flexible ureteroscopic holmium laser lithotripsy. Results There were significant differences in age, gender, number of stones, stone diameter,operation time, serum creatinine, urea nitrogen, C-reactive protein, and procalcitonin between the two groups(P <0.05). Multiple stones, stone diameter ≥20 mm, serum creatinine, urea nitrogen, C-reactive protein, and procalcitonin were the influencing factors of urinary sepsis after flexible ureteroscopic holmium laser lithotripsy(OR > 1, P < 0.05).Conclusion The multiple calculi, calculi diameter ≥20 mm, serum creatinine abnormity, blood urea nitrogen abnormity, C-reactive protein abnormity, procalcitonin abnormity of patients were influencing factors of urinary sepsis,actively intervention has positive significance in reducing postoperative complications of urinary sepsis.更多还原