【摘要】 目的 初步探索原发性发育迟滞（DD）患儿血清维生素A、25-羟-维生素D₃、维生素E含量及其与神经发育的相关性。方法 选取2019年3月至2020年2月首都儿科研究所附属儿童医院（以下简称“我院”）神经内科就诊的原发性DD患儿33例为原发性DD组，另选取同期在我院保健科进行健康体检的30名儿童作为健康对照组。采用高效液相色谱串联质谱法测定两组血清维生素A、25-羟-维生素D₃、维生素E的含量。采用《0岁-6岁儿童发育行为评估量表》评估原发性DD患儿的神经发育水平，并将各能区评分与维生素含量进行相关性分析。结果 原发性DD组维生素A含量和25-羟-维生素D₃含量低于健康对照组（P <0.05）。两组血清维生素E含量比较，差异无统计学意义（P> 0.05）。原发性DD组维生素A、25-羟-维生素D₃及维生素E不足率高于健康对照组（P <0.05）。25-羟-维生素D₃含量与精细运动能区得分呈正相关（r=0.375,P <0.05）。维生素A和25-羟-维生素D₃为原发性DD的保护因素（OR <1,P <0.05）。结论 原发性DD患儿血清维生素A及25-羟-维生素D₃含量显著低于同龄健康儿童，血清25-羟-维生素D₃缺乏对儿童精细运动的发育存在影响。更多还原

【Abstract】 Objective To preliminarily analyse the serum levels of vitamin A, 25-hydroxy-vitamin D₃, and vitamin E in children with primary development delay（DD） and their correlation with neurodevelopment. Methods Thirty-three children with primary DD who were treated in the Department of Neurology, Children’s Hospital, Capital Institute of Pediatrics（hereinafter referred to as “our hospital”） from March 2019 to February 2020 were selected as primary DD group, and 30 children who underwent routine physical examinations in the Department of Child Health during the same period served as healthy control group. The serum level of vitamin A, 25-hydroxy-vitamin D₃, and vitamin E of two groups were measuerd by high performance liquid chromatography tandem mass spectrometry. The neurodevelopmental level of children with primary DD was evaluated by developmental scale for children aged0-6 years, and the correlation between the scores of each functional area and vitamin content was analyzed.Results The serum level of vitamin A and 25-hydroxy-vitamin D₃ in primary DD group were lower than those in healthy control group（P < 0.05）. There was no significant difference in serum vitamin E content between two groups（P >0.05）. The deficiency rates of vitamin A, 25-hydroxyvitamin D₃, and vitamin E in primary DD group were higher than those in healthy control group（P < 0.05）. The level of 25-hydroxy-vitamin D₃ was positively correlated with the score in the fine motion dimension（r = 0.375, P < 0.05）. Vitamin A and 25-hydroxy-vitamin D₃ were protective factors for primary DD（OR < 1, P < 0.05）. Conclusion The serum levels of vitamin A and 25-hydroxy-vitamin D₃ in primary DD children are significantly lower than those of healthy children of the same age, serum 25-hydroxy-vitamin D₃ deficiency affects fine motor development in children.更多还原