【摘要】 人类C反应蛋白（CRP）的基线水平以CRP基因中存在的单核苷酸多态性影响最为显著并具有个体差异，近年来流行病学和研究发现CRP基因中的遗传多态性所致的CRP水平升高与癌症风险增加，肿瘤的增殖、转移及不良预后等密切相关。此外，基因组上一些相关参与调控CRP水平的单核苷酸多态性位点不断被发现并具有相同的功能。但一些研究发现遗传性升高的CRP水平与癌症发生并无因果关系。目前认为这些差异可能与不同的种族、地域、样本量、环境和遗传因素等有关。本文对CRP基因多态性与肿瘤发生发展之间的研究进展作一综述，以期为探讨CRP基因多态性与肿瘤免疫相关病因学途径的发病机制研究提供参考。更多还原

【Abstract】 The baseline level of human C-reactive protein(CRP) is most significant influenced by single nucleotide polymorphism in CRP gene and has individual differences. In recent years, epidemiology and research have found that the increased CRP level caused by genetic polymorphism in CRP gene is closely related to the increased risk of cancer and the proliferation and metastasis of tumors and poor prognosis. In addition, a number of genome-wide single nucleotide polymorphisms that are involved in the regulation of CRP levels are being identified and have similar functions. But some studies have found no causal relationship between genetically elevated CRP levels and cancer. It is believed that these differences may be related to different races, regions, sample sizes, environmental factors and genetic factors. This article reviews the research progress of CRP gene polymorphism and tumorigenesis and development, in order to provide reference for the study of the pathogenesis of CRP gene polymorphism and tumor immune-related etiology pathway.更多还原