【摘要】 目的 通过数据挖掘方法分析国家专利中药复方干预糖尿病足（DF）的用药规律，为临床选方用药提供参考。方法 在国家知识产权局网站内的中国专利公布公告界面，以“‘糖尿病足’and‘中药’”“‘糖尿病足’and‘中医’”“‘消渴脱疽’and‘中药’”为检索关键词，检索时间为建库至2021年8月30日，检索中药治疗DF的专利。用Excel 2019进行频数统计，运用SPSS Modeler 18.0、SPSS 26.0和Cytoscape 3.7.2软件分别进行关联规则、系统聚类分析，挖掘核心中药组合。结果 共纳入56项专利和56个中药复方组合；共有270味中药，出现频次较高的前3位分别是黄芪、当归、丹参；四气以辛、咸为主，五味以温、寒为主，归经以脾、肝经居多；中药关联规则中支持度排名前10位的有黄芪-丹参、黄芪-川芎、黄芪-红花等；系统聚类分析将排名前30位的中药分为7组；新处方包含黄芪、丹参、当归、赤芍等药物。结论 中药复方治疗DF多选用黄芪配伍活血化瘀中药，并根据兼夹症不同，选用不同的核心药物组合。更多还原

【Abstract】 Objective To analyze medication rules of national patents on Chinese medicine compounds in the intervention for diabetic foot(DF) based on data mining method, and to provide references for the optimization of clinical prescriptions and medications. Methods In the Chinese patent announcement interface of China National Intellectual Property Administration website, “‘diabetic foot’ and ‘traditional Chinese medicine’”, “‘diabetic foot’ and ‘Chinese herb’”, and “‘gangrene of consumptive thirst’ and ‘Chinese herb’” were used as search terms, and the search period was from the establishment of the database to August 30, 2021, in order to search the patents of Chinese herbs treating DF. Frequency statistics were performed by Excel 2019, and association rules and systematic cluster analysis were performed by using SPSS Modeler 18.0, SPSS 26.0, and Cytoscape 3.7.2 softwares, respectively, in order to mine the core Chinese herbs combinations. Results A total of 56 patents and 56 traditional Chinese medicine compound combinations were included; there were 270 kinds of Chinese herbs, and the top three with high frequency were Astragali Radix, Angelicae Sinensis Radix, and Salviae Miltiorrhizae Radix Et Rhizoma; the four nature of drugs were mainly pungent and salty, the five flavors were mainly warm and cold, the spleen and liver meridians were in the majority; the top ten supporting of Chinese medicine association rules were Astragali Radix-Salviae Miltiorrhizae Radix Et Rhizoma, Astragali Radix-Chuanxiong Rhizoma, Astragali Radix-Carthami Flos, etc.; the top 30 Chinese herbs were divided into seven groups by systematic cluster analysis; the new prescriptions included Astragali Radix, Salviae Miltiorrhizae Radix Et Rhizoma, Angelicae Sinensis Radix, and Paeoniae Radix Rubra. Conclusion In the treatment of DF, Astragali Radix combined with traditional Chinese medicine for promoting blood circulation and removing blood stasis is mostly used, and different core drug combinations are selected according to the different double clip syndrome.更多还原