【摘要】 目的 通过研究超重/肥胖症人群血清磷脂脂肪酸谱的变化，并分析其与血脂代谢的相关性。方法 采用随机数字表法分别从体检人群中抽取超重/肥胖症组(n=43)和对照组(n=52)作为研究对象，测定所有受试者的血清磷脂脂肪酸谱，以及血甘油三酯(triacylglycerol, TG)、胆固醇(cholesterol, TC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol, LDL-C),测定腰臀比(waist-to-hip ratio, WHR)和体重指数(body mass index, BMI)。采用Pearson相关分析分析超重/肥胖症组血清磷脂脂肪酸与血脂水平的相关性。结果 超重/肥胖症组C20∶4η-6百分比含量显著高于对照组(2.0%±0.7%vs 1.7%±0.7%,P<0.05),而C20∶1(0.3%±0.1%vs 0.4%±0.1%,P<0.01)和多不饱和脂肪酸(polyunsaturated fatty acid, PUFA)(42.7%±5.3%vs 44.5%±3.4%,P<0.05)显著低于对照组。超重/肥胖症组与对照组比较，TG显著高于对照组(2.1±2.4mmol/L vs 1.0±0.7mmol/L,P<0.01);超重/肥胖症组HDL-C(1.3±0.3mmol/L vs 1.6±0.4mmol/L,P<0.001)和HDL-C/TC (0.3±0.1 vs 0.6±0.1,P<0.001)显著下降。相关性分析显示，超重/肥胖症组TC与C22∶4η-6呈显著负相关；TG与C16∶1、C18∶1、C18∶3η-3、单不饱和脂肪酸(monounsaturated fatty acid, MUFA)呈正相关，而TG与C20∶5η-3、C23∶0、C22∶6η-3、ω-3PUFA和ω-3/ω-6PUFA呈负相关；HDL-C与C16∶1、C20∶0呈正相关(P<0.05)。结论 超重/肥胖症组血清磷脂脂肪酸谱发生异常改变，并与其脂代谢异常密切相关，特别是超重/肥胖症人群TG升高可能与MUFA有关，而ω-3PUFA降低可能引起或加重其血脂代谢紊乱。更多还原

【Abstract】 Objective To investigate the relationship of serum phospholipid fatty acid profile in overweight or obese patients, and analyzing its correlation with blood lipid metabolism. Methods We randomly selected the overweight or obesity group(n=43) and the control group(n=52) from the physical examination population as the research objects. The serum phospholipid fatty acid profile of all subjects was measured. And serum triacylglycerol(TG), cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C) of each group were detected, and the waist to hip ratio(WHR) and body mass index(BMI) were determined. Pearson correlation analysis was used to analyze the correlation between serum phospholipid fatty acids and blood lipid levels in the overweight or obesity group. Results The C20∶4η-6 percentage content in the overweight or obesity group was significantly higher than that the control group(2.0%±0.7% vs 1.7%±0.7%,P<0.05), while C20∶1(0.3%±0.1% vs 0.4%±0.1%,P<0.01) and polyunsaturated fatty acids(PUFA)(42.7%±5.3% vs 44.5%±3.4%,P<0.05) were significantly lower than the control group. Compared with the control group, TG of the overweight or obesity group were significantly higher(2.1±2.4mmol/L vs 1.0±0.7mmol/L,P<0.01). HDL-C(1.3±0.3mmol/L vs 1.6±0.4mmol/L,P<0.001)and HDL-C/TC(0.3±0.1 vs 0.6±0.1,P<0.001) of the overweight or obesity group were significantly decreased. Correlation analysis showed that TC in the overweight or obesity group was significantly negatively correlated with C22∶4η-6. TG were positively correlated with C16∶1, C18∶1, C18∶3η-3, monounsaturated fatty acids(MUFA), and TG were negatively correlated with C20∶5η-3, C23∶0, C22∶6η-3, ω-3 PUFA and ω-3/ω-6 PUFA. HDL-C were positively correlated with C16∶1, C20∶0(P<0.05). Conclusion The overweight or obese group has abnormal changes in serum phospholipid fatty acid profile and is closely related to abnormal lipid metabolism. In particular, MUFA may be related to the increase of TG in overweight/obese patients, and the decrease of ω-3PUFA may cause or aggravate the disorder of blood lipid metabolism.更多还原