【摘要】 目的 分析子宫内膜增生症合并不孕症患者保守治疗后行体外受精/卵胞质内单精子注射-胚胎移植(in vitro fertilization/intracytoplasmic sperm injection-embryo transfer, IVF/ICSI-ET)的助孕结局。方法 收集2017年5月～2020年6月在潍坊医学院附属医院生殖医学中心就诊行体外受精/卵胞质内单精子注射-胚胎移植的179例不孕症患者，根据内膜病理分为子宫内膜增生症组(研究组，n=87)和子宫内膜正常组(对照组，n=92);根据是否伴有多囊卵巢综合征(polycystic ovary syndrome, PCOS)将研究组分为PCOS组(n=37)和非PCOS组(n=50)。回顾性分析各组患者行IVF/ICSI-ET的结局。结果 研究组基础黄体生成素(bLH)水平低于对照组(4.37±0.04IU/L vs 5.75±0.04IU/L),两组间其他基本资料比较，差异均无统计学意义(P均>0.05)。研究组共行鲜胚移植44个周期，冻融胚胎移植(frozen embryo transfer, F-ET)40个周期，对照组共行鲜胚移植33个周期，F-ET 54个周期，两组间鲜胚移植及F-ET妊娠结局比较，差异均无统计学意义(P均>0.05)。两亚组间妊娠结局比较，差异无统计学意义(P>0.05)。结论 子宫内膜增生合并不孕症患者经保守治疗后行IVF/ICSI-ET可以得到较好的妊娠结局；伴有PCOS并不影响子宫内膜增生症患者行IVF/ICSI-ET的妊娠结局。更多还原

【Abstract】 Objective To analyze assisted pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET) in patients with endometrial hyperplasia after conservative treatment. Methods A total of 179 infertile patients who underwent IVF/ICSI-ET in our Reproductive Medicine Center from May 2017 to June 2020 were collected and divided into study group(87 cases) and control group(92 cases) according to the endometrial pathological results. Study group was divided into PCOS group(37 cases) and non-PCOS group(50 cases) depending on whether there was polycystic ovary syndrome(PCOS). Pregnancy outcomes of each group after IVF/ICSI-ET were analyzed retrospectively. Results The level of basic luteinizing hormone(bLH) in study group was lower than that in control group(4.37±0.04 IU/L vs 5.75±0.04 IU/L, P=0.021). There were 44 cycles of fresh embryo transfer and 40 cycles of frozen embryo transfer(F-ET) in the study group, There also were 33 cycles of fresh embryo transfer and 54 cycles of F-ET in the control group. There was no significant difference in fresh embryo transfer and F-ET pregnancy outcomes between the two groups(P>0.05). There was no significant difference in pregnancy outcome between the two subgroups(P>0.05). Conclusion Patients with endometrial hyperplasia can get good pregnancy outcomes by IVF/ICSI-ET after conservative treatment. The presence of PCOS did not affect outcomes of IVF/ICSI-ET in patients with endometrial hyperplasia.更多还原