【摘要】 目的 探讨¹⁸F-FDG PET/CT显像对临床前列腺癌生化复发转移灶的评估价值。方法 回顾性研究因临床诊断生化复发行¹⁸F-FDG PET/CT的成年男性患者15例，患者年龄52～81岁，平均年龄68±9岁。完善同期MRI、CT及骨显像结果的收集，以及PET/CT检查后随访。以最终临床医生综合影像及病理等各方面信息后做出的最终诊断为诊断标准，分析PET/CT图像的影像学结果，并和同期其他影像学检查对照，比较PET/CT及其他检查方法的诊断效能。结果 ¹⁸F-FDG PET/CT诊断前列腺癌生化复发显像阳性率67%（10/15）,尿道转移漏诊1例，总体敏感度、特异性及准确性分别为91%、100%及93%,阳性预测值100%,阴性预测值80%。¹⁸F-FDG PET/CT与同期MRI对比，同一显像范围内二者的诊断敏感度、特异性、准确性分别为88%和71%、100%和86%、93%和79%。骨盆外转移灶，¹⁸F-FDG PET/CT阳性率为33%,敏感度、特异性及准确性均为100%。同期行CT及骨显像者，检查结果准确性均低于PET/CT。结论 ¹⁸F-FDG PET/CT能够较传统影像检查更准确地探测生化复发的转移灶，对盆腔以外的病灶更具优势。更多还原

【Abstract】 Objective To determine the value of ¹⁸F-FDG PET/CT in evaluating the metastases biochemical recurrence of prostate cancer. Methods Fifteen patients with 52-81 year-old（mean: 68±9） who were diagnosed as prostate cancer biochemical recurrence and referred for ¹⁸F-FDG PET/CT scan were prospectively enrolled.The PET/CT and MRI images of the patients were analyzed. The final results were confirmed by follow-up and pathology retrospectively. We compared the result of PET/CT and the other imaging methods.Sensitivity（SE）, specificity（SP）, accuracy（ACC）, positive predictive values（PPV）, negative predictive values（NPV） and accuracy were calculated. Results The positive rate of ¹⁸F-FDG PET/CT was 67%（10/15）. A urethral metastasis lesion is missed. SE, SP and ACC of ¹⁸F-FDG imaging was 91%, 100% and 93%, respectively. PPV and NPV was and 100% and 80%. For the lesions in the same scan field, SE, SP and ACC of PET/CT was 88%, 100% and 93%, respectively, whereas the corresponding value of MRI was 71%, 86% and 79%. For the lesions outside the pelvis, SE, SP and ACC of PET/CT was 100%. ACC of CT scan and bone scan was lower than ¹⁸F-FDG PET/CT. Conclusion In biochemical recurrence of prostate cancer, ¹⁸F-FDG PET/CT is useful in the detection of occult metastases, whereas the yield of conventional imaging methods are relatively limited.更多还原