【摘要】 荜茇酰胺（piperlongumine）是一种具有抗炎、抗肿瘤活性的生物碱。研究表明，荜茇酰胺对恶性肿瘤细胞如乳腺癌、肺癌、前列腺癌、结直肠癌等有促进细胞凋亡、细胞周期阻滞、抑制血管生成及肿瘤侵袭转移、增加细胞内活性氧等作用。同时，荜茇酰胺对逆转肿瘤耐药、增加放化疗敏感性有着显著作用。本文主要对荜茇酰胺和活性氧进行概述，对荜茇酰胺放射增敏的主要机制及荜茇酰胺在不同恶性肿瘤放射增敏中的应用作一综述，以期为荜茇酰胺在放疗增敏的应用提供理论依据。更多还原

【Abstract】 Piperlongumine is an alkaloid with anti-inflammatory and anti-tumor activities. Studies have shown that Piperlongumine can promote apoptosis, block cell cycle, inhibit angiogenesis, tumor invasion and metastasis, and increase intracellular reactive oxygen species for malignant tumor cells such as breast cancer, lung cancer, prostate cancer, and colorectal cancer. Studies have shown that Piperlongumine has a significant effect on reversing tumor resistance and increasing the sensitivity of radiotherapy and chemotherapy. This paper will summarize Piperlongumine and active oxygen species, and review the main mechanism of piperlongumine radiosensitization and its application in different malignant tumors, in order to provide theoretical basis for the application of Piperlongumine in radiosensitization by radiotherapy.更多还原