【摘要】 目的 分析椎体转移患者放疗期间爆发痛的影响因素。方法 收集2015年1月-2018年12月华中科技大学同济医学院附属同济医院317例椎体转移恶性肿瘤放疗患者的临床资料，均进行椎体的X线外照射放疗。根据放疗期间爆发痛发生情况分为放疗爆发痛组和无放疗爆发痛组，比较两组临床特征，并采用多因素Logistic回归分析椎体转移患者放疗期间爆发痛的影响因素。结果 317例椎体转移患者中有145例患者在放疗期间发生爆发痛，发生率为45.74%。两组性别、KPS评分、放疗部位比较，差异有统计学意义（P<0.05）；而两组年龄﹑原发肿瘤部位、VRS基础疼痛评分﹑放疗剂量﹑放疗椎体数比较，差异无统计学意义（P>0.05）；多因素Logistic回归分析显示，女性、高KPS评分、颈椎/胸椎转移是椎体转移患者放疗期间爆发痛的影响因素（P<0.05）。结论女性、高KPS评分、颈椎/胸椎转移患者在放疗期间发生爆发痛的风险较高。更多还原

【Abstract】 Objective To analyze the influencing factors of burst pain in patients with vertebral metastasis during radiotherapy.Methods The clinical data of 317 patients with malignant tumor of vertebral metastasis treated with radiotherapy in Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from January 2015 to December 2018 were collected, and all the patients were treated with X-ray external radiotherapy of vertebral body. According to the occurrence of burst pain during radiotherapy, the patients were divided into burst pain group and no burst pain group. The clinical characteristics of the two groups were compared, and the influencing factors of burst pain during radiotherapy in patients with vertebral metastasis were analyzed by multivariate Logistic regression.Results Burst pain occurred in 145 of the 317 patients with vertebral metastasis during radiotherapy, with the incidence of 45.74%. There were significant differences in gender, KPS score and radiotherapy site between the two groups(P<0.05). There was no significant difference in age, primary tumor site, VRS basic pain score, radiotherapy dose, and number of vertebrae between the two groups(P >0.05). Multivariate Logistic regression analysis showed that female, high KPS score and cervical/thoracic metastasis were the influencing factors of burst pain in patients with vertebral metastasis during radiotherapy( P<0.05).Conclusion Female, high KPS score and cervical/thoracic metastasis patients have higher risk of burst pain during radiotherapy.更多还原